货号：04-1068

品牌：Merck Millipore

规格：

目录价：￥3788.00

市场价格：￥3219.80

会员价格：￥3030.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PSD95 (Ser418) Antibody, clone EPR2618Y, Rabbit | 04-1068 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects PSD95 phosphorylated at Ser418. View All» Molecular Weight: ~95 kDa View All» Immunogen: Phospho-synthetic peptide corresponding to residues surrounding Ser418 of human PSD95. View All» Modifications: Phosphorylation View All» Clone: EPR2618Y View All» Isotype: IgG View All» Background Information: PSD95 (postsynaptic density95) represent a class of anchoring proteins which serve to localize various neuronal ion channels to post-synaptic densities. PSD95 and related proteins contain PDZ domains, which interact with NMDA receptors and voltage-gated K+ channels via a ET/SXV motif in the cytoplasmic carboxyl terminus of the receptor channels. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Mouse and rat. Predicted to react with human based on sequence homology. View All» Control: Rat brain lysate View All» Quality Assurance: Evaluated by Western Blot on untreated and alkaline phosphatase treated rat brain lysates.Western Blot Analysis: 1:500 dilution of this antibody was used to detect PSD95 on untreated and alkaline phosphatase treated rat brain lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P78352 View All» Entrez Gene Number: NP_001122299.1 View All» Gene Symbol:
  • FLJ97752

  • FLJ98574

  • PSD-95

  • PSD95

  • SAP-90

  • SAP90
    View All» Alternate Names:
    • Postsynaptic density protein 95

    • Synapse-associated protein 90

    • Tax interaction protein 15

    • discs large homolog 4

    • discs, large homolog 4 (Drosophila)

    • post-synaptic density protein 95
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B By similarity.SUBUNIT STRUCTURE: Interacts with ANKS1B and PRR7 By similarity. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ACCN3, certain splice forms of GRIN1, KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A and BEGAIN. Interacts through its third PDZ domain with CRIPT By similarity. Interacts through its first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with LRFN1.SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Note: High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. TISSUE SPECIFICITY: Brain.DOMAIN: The PDZ domain 3 mediates interaction with ADR1B.The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density.PTM: Palmitoylation of isoform 1 is required for targeting to postsynaptic density By similarity.SEQUENCE SIMILARITIES: Belongs to the MAGUK family.Contains 1 guanylate kinase-like domain.Contains 3 PDZ (DHR) domains.Contains 1 SH3 domain. View All» Product Name: Anti-phospho-PSD95 (Ser418), clone EPR2618Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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