货号：MAB3662

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Transcriptional Intermediary Factor 1 Antibody, β | MAB3662 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes transcriptional intermediary factor 1beta (TIF1beta). The epitope is localized between amino acids 123-834 of mouse TIF1beta. No cross reactivity with TIF1alpha. View All» Immunogen: Recombinant protein from mouse TIF1b. View All» Isotype: IgG2b View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot: 1:500-1:5,000 Immunocytochemistry: 1:500-1:5,000 ELISA: 1:500-1:5,000 Optimal working dilutions must be determined by the end user. View All» Presentation: Ascites. Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q13263 View All» Entrez Gene Number: NM_005762.2 View All» Gene Symbol:
  • TRIM28

  • FLJ29029

  • TIF1B

  • RNF96

  • TF1B

  • KAP-1

  • KRIP-1

  • TIF1-beta

  • KAP1
    View All» Alternate Names: TIF1beta View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. View All» UniProt Summary: FUNCTION: SwissProt: Q13263 # Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene (By similarity).SIZE: 835 amino acids; 88550 Da SUBUNIT: Associated with HP1 alpha (CBX5), beta (CBX1) and gamma (CBX3) in interphase nuclei (By similarity). Interacts with NCOR1 and CHD3. Interacts with SETDB1, ZFP53 and ZFP68. Interacts with CEBPB and NR3C1 (By similarity). Interacts directly with CBX5 via the PxVxL motif.SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Associated with centromeric heterochromatin during cell differentiation through CBX1 (By similarity).DOMAIN: SwissProt: Q13263 The HP1 box is both necessary and sufficient for HP1 binding. The RING finger domain and the B-box domains mediate interaction with CEBPB. The PHD domain enhances the CEBPB transcriptional activity (By similarity). & Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Belongs to the TRIM/RBCC family. & Contains 2 B box-type zinc fingers. & Contains 1 bromo domain. & Contains 1 PHD-type zinc finger. & Contains 1 RING-type zinc finger. View All» Brand Family: Chemicon View All» Product Name: Anti-Transcriptional Intermediary Factor 1 Antibody, β | MAB3662 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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