货号：MAB366

品牌：Merck Millipore

规格：100UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAP1B Antibody, clone AA6 | MAB366 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts specifically with MAP1B (MAP5) by immunoblot. Shows selective staining of dendritic trees throughout the brain. No cross-reactivity observed to other MAPs or tubulin. Monoclonal Anti-MAP1b is immunospecific for MAP1b (also known as MAP5, MAPIX or MAP1.2; Riederer et al., 1986; Tucker et al., 1988) as determined by an immunoblot assay. Addition of antibody to microtubule proteins before polymerization results in abnormally short (but otherwise morphologically normal) microtubules. View All» Immunogen: Rat brain microtubule-associated protein. View All» Clone: AA6 View All» Isotype: IgG1 View All» Species Reactivity:

• Bovine

• Chicken

• Hamster

• Mouse

• Rat

• Feline
  View All» Application Notes: Immunoblotting at 1:300-1:500. Immunohistochemistry Optimal working dilutions must be determined by the end user. View All» Presentation: Ascites. Liquid containing 15mM sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P46821 View All» Entrez Gene Number:
  • NM_032010.1

  • NM_005909.3
    View All» Gene Symbol:
    • MAP1B

    • DKFZp686F1345

    • FUTSCH

    • DKFZp686E1099

    • MAP5

    • FLJ38954
      View All» Alternate Names: MAP5 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. View All» UniProt Summary: FUNCTION: SwissProt: P46821 # The function of brain MAPS is essentially unknown. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B Binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.SIZE: 2468 amino acids; 270620 Da SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino- terminal region of MAP1B. Interacts with ANP32A (By similarity).DOMAIN: SwissProt: P46821 Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules.PTM: LC1 is generated from MAP1B by proteolytic processing. & Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Belongs to the MAP1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-MAP1B Antibody, clone AA6 | MAB366 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Cytoplasmic, soma, dendritic View All» Format: Ascites View All» Host: Mouse View All»
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