货号：04-1056

品牌：Merck Millipore

规格：

目录价：￥3615.00

市场价格：￥3072.75

会员价格：￥2892.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IDO Antibody, clone EPR1230Y, Rabbit | 04-1056 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: This antibody recognizes IDO. View All» Molecular Weight: ~42 kDa View All» Immunogen: Synthetic peptide corresponding to residues within human IDO. View All» Clone: EPR1230Y View All» Isotype: IgG View All» Background Information: Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in thesuppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy. View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Control: HeLa + IFN-γ cell lysate View All» Quality Assurance: Evaluated by Western Blotting on HeLa + IFN-γ cell lysates.Western Blotting Analysis: 1:2,500-5,000 dilution of this antibody detected IDO in HeLa + IFN-γ cell lysate. View All» Presentation: Rabbit Monoclonal IgG in buffer containing 50mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P14902 View All» Entrez Gene Number: NP_002155.1 View All» Gene Symbol:

• IDO

• INDO
  View All» Alternate Names:
  • Indoleamine-pyrrole 2,3-dioxygenase

  • indole 2,3-dioxygenase

  • indoleamine 2,3-dioxygenase 1

  • indoleamine-pyrrole 2,3 dioxygenase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Gamma-interferon (IFNG; MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.52). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine.[supplied by OMIM] View All» UniProt Summary: FUNCTION: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.CATALYTIC ACTIVITY: D-tryptophan + O2 = N-formyl-D-kynurenine.L-tryptophan + O2 = N-formyl-L-kynurenine.COFACTOR: Binds 1 heme group per subunit.INDUCTION: By interferon gamma.SEQUENCE SIMILARITIES: Belongs to the indoleamine 2,3-dioxygenase family View All» Product Name: Anti-IDO Antibody, clone EPR1230Y, Rabbit | 04-1056 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Host: Rabbit View All»
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