货号：04-1054

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-S100-β (C-term) Antibody, clone EP1576Y, Rabbit | 04-1054 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes S100-β at and around the C-terminus. View All» Molecular Weight: ~11 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues on the C-terminus of human S100-β. View All» Clone: EP1576Y View All» Isotype: IgG View All» Background Information: S-100 protein is a member of the EF-hand calcium-binding protein superfamily that is widely distributed and conserved in the central nervous system of vertebrates. The protein exists in both heterodimeric and homodimeric forms. The two subunits of S-100 protein are the products of separate genes that are differentially expressed by various cells. The beta subunit is present in all S-100 positive cells and tumors. In contrast, the alpha subunit is detectable only in heart, skeletal muscle and brain. In addition to its calcium binding properties, S-100 protein has a high-affinity binding site for zinc and is involved in the regulation of protein phosphorylation in the brain. The protein apparently plays a role in cell differentiation and growth, cytoskeletal structure and function, and has been implicated in neuropathological diseases. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected S100-β in human melanoma tissue.Immunoprecipitation Analysis: A 1:40 dilution from a previous lot was used in IP. View All» Control: A375 cell lysate View All» Quality Assurance: Evaluated by Western Blot on A375 cell lysates.Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect S100-β in A375 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P04271 View All» Entrez Gene Number: NP_006263.1 View All» Gene Symbol:
  • NEF

  • OTTHUMP00000174958

  • S100

  • S100beta
    View All» Alternate Names:
    • S-100 calcium-binding protein, beta chain

    • S-100 protein beta chain

    • S-100 protein subunit beta

    • S100 beta

    • S100 calcium binding protein B

    • S100 calcium binding protein, beta (neural)

    • S100 calcium-binding protein B

    • S100 calcium-binding protein, beta

    • S100 calcium-binding protein, beta (neural)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. View All» UniProt Summary: FUNCTION: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase.SUBUNIT STRUCTURE: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38 By similarity. The S100B dimer interacts with two molecules of CAPZA1.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.MISCELLANEOUS: In addition to metal-ion binding, this protein is involved with the regulation of protein phosphorylation in brain tissue.SEQUENCE SIMILARITIES: Belongs to the S-101 family.Contains 2 EF-hand domains. View All» Product Name: Anti-S100-β (C-term), clone EP1576Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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