货号：MAB360

品牌：Merck Millipore

规格：100Ul

目录价：￥4131.00

市场价格：￥3511.35

会员价格：￥3304.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5 | MAB360 View All» Promotional Text: Special Shipping Offer on Antibodies 100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Glial fibrillar acidic protein. On western blots of extracts from a human glioma cell line (U33CG/343MG), MAB360 recognizes a band at approximately 51 kDa corresponding to GFAP (Debus, 1983). By immunohistochemistry it recognizes astrocytes and Bergmann glia cells, glioma and glial cell derived tumors. Shows no cross-reactivity with vimentin. View All» Molecular Weight: ~ 51 kDa View All» Immunogen: Purified GFAP from porcine spinal cord. View All» Clone: GA5 View All» Isotype: IgG1 View All» Background Information: Glial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system. View All» Species Reactivity:

• Bovine

• Chicken

• Human

• Mouse

• Pig

• Rat

• Rabbit
  View All» Species Reactivity Note: Reacts with Bovine, Chicken, Human, Mouse, Porcine (Pig), Rabbit and Rat. Reactivity with other species has not been determined. View All» Application Notes: Immunocytochemistry: A previous lot was used on cultured mammalian cells. Immunohistochemistry(paraffin): 1:400-1:800 dilution from a previous lot was used on alcohol-fixed paraffin embedded sections of rat brain (cerebrum or cerebellum) and human brain. Immunoblotting: A 1:1000 dilution of a previous lot was used. Optimal working dilutions must be determined by the end user View All» Control: Positive Control: Cultured astrocytes, brain tissue (white matter), spinal chord, retina View All» Quality Assurance: Routinely evaluated by Western Blot on Mouse brain lysates. Western Blot Analysis: 1:1000 dilution of this lot detected GFAP on 10 μg of Mouse brain lysates. View All» Purification Method: Unpurified View All» Presentation: Unpurified mouse monoclonal IgG1 liquid in buffer containing 15 mM sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P14136 View All» Entrez Gene Number: NM_002055.2 View All» Gene Symbol:
  • GFAP

  • FLJ45472
    View All» Alternate Names: GFAP View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. SIZE: 432 amino acids; 49880 Da SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1. SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments. DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family. View All» Brand Family: Chemicon View All» Product Name: Anti-Glial Fibrillary Acidic Protein Antibody, clone GA5 | MAB360 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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