货号：MAB3584

品牌：Merck Millipore

规格：100UL

目录价：￥8123.00

市场价格：￥6904.55

会员价格：￥6498.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5 | MAB3584 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with Heterochromatin protein-1 alpha (HP1alpha) between amino acids 67 and 119. View All» Immunogen: Recombinant mouse HP1a. View All» Clone: 2HP-1H5 View All» Isotype: IgG1κ View All» Background Information: Chromatin assembly factor-1 (CAF-1) is a multisubunit protein complex that comprises three polypeptide subunits known as p150, p60, and p48. CAF-1 is a nucleosome assembly factor that deposits newly synthesized and acetylated histones H3/H4 into nascent chromatin during DNA replication. Heterochromatin is characterized as densely coiled chromatin that generally replicates late during S phase, has a low gene density, and contains large blocks of repetitive DNA that is relatively inaccessible to DNA-modifying reagents. In late S phase, p150 directly associates with heterochromatin associated proteins 1 (HP1α, HP1β and HP1γ). As cells prepare for mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin, coinciding with the phosphorylation of histone H3. The HP1 proteins reassociate with chromatin at the end of mitosis, as histone H3 is dephosphorylated. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Immunocytochemistry: 1:500-1:5,000 Immunohistochemistry: 1:500-1:5,000 ELISA: 1:500-1:5,000 Western blot: not recommended. For Western blot use MAB3446. Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended: Western Blotting View All» Control: Positive Control: HeLa cells, 3T3 cells , F9 cells, mouse embryos View All» Purification Method: Unpurified View All» Presentation: Liquid ascites no preservative. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P45973 View All» Entrez Gene Number: NM_012117.1 View All» Gene Symbol:
  • CBX5

  • HP1-ALPHA

  • HP1A

  • HP1

  • HP1Hs-alpha
    View All» Alternate Names: HP1a; Antigen p25; Chromobox Protein Homolog 5 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P45973 # Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Can interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.SIZE: 191 amino acids; 22225 Da SUBUNIT: Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with MIS12 and C20orf127.SUBCELLULAR LOCATION: Nucleus. Centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.PTM: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper- phosphorylated during mitosis.SIMILARITY: SwissProt: P45973 ## Contains 2 chromo domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5 | MAB3584 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Ascites View All» Host: Mouse View All»
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