货号：04-1048

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-2 Antibody, clone EP1183Y, Rabbit | 04-1048 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects both the pro- and active forms of MMP-2. View All» Molecular Weight: ~ 72 (propeptide)/64 (active) kDa View All» Immunogen: Synthetic peptide corresponding to residues on human MMP-2. View All» Clone: EP1183Y View All» Isotype: IgG View All» Background Information: The matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, lupus, arthritis, periodontis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Control: Recombinant protein View All» Quality Assurance: Evaluated by Western Blot using Anti-MMP-2.Western Blot Analysis: 1:1000 dilution of this antibody was used to detect MMP-2. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P08253 View All» Entrez Gene Number: P08253 View All» Gene Symbol:
  • CLG4

  • CLG4A

  • EC 3.4.24.24

  • MMP-2

  • MMP-II

  • MONA

  • TBE-1
    View All» Alternate Names:
    • 72 kDa gelatinase

    • Gelatinase A

    • Matrix metalloproteinase-2

    • collagenase type IV-A

    • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

    • matrix metalloproteinase 2

    • matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase)

    • matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

    • matrix metalloproteinase-II

    • neutrophil gelatinase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-|-Leu bond.CATALYTIC ACTIVITY: Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.COFACTOR: Binds 4 calcium ions per subunit.Binds 2 zinc ions per subunit.ENZYME REGULATION: Inhibited by histatin-3 1/24 (histatin-5). SUBUNIT STRUCTURE: Ligand for integrin alpha-V/beta-3.SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix Probable. TISSUE SPECIFICITY: Produced by normal skin fibroblasts.DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3).INVOLVEMENT IN DISEASE: Defects in MMP2 are the cause of Torg-Winchester syndrome [MIM:259600]; also called multicentric osteolysis nodulosis and arthropathy (MONA). Torg-Winchester syndrome is an autosomal recessive osteolysis syndrome. It is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Torg-Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes.SEQUENCE SIMILARITIES: Belongs to the peptidase M10A family.Contains 3 fibronectin type-II domains.Contains 4 hemopexin-like domains. View All» Product Name: Anti-MMP-2, clone EP1183Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-131222.htm
      © Merck Millipore代理04-1048 Anti-MMP-2, clone EP1183Y, Rabbit Monoclonal，产品报价联系微信jinshanbio