货号：04-1045

品牌：Merck Millipore

规格：

目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Caspase-6 (Pro) Antibody, clone EP1325Y, Rabbit | 04-1045 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes pro-Caspase 6. View All» Molecular Weight: ~35 kDa View All» Immunogen: Synthetic peptide corresponding to residues of human pro-Caspase-6. View All» Clone: EP1325Y View All» Isotype: IgG View All» Background Information: Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Proven to react in human. View All» Application Notes: Immunohistochemistry Analysis: A 1:100 - 250 dilution from a previous lot detected pro-Caspase 6 in human breast carcinoma tissue and HeLa cell lysate. View All» Control: MCF-7 cell lysates View All» Quality Assurance: Evaluated by Western Blotting on MCF-7 cell lysates.Western Blotting Analysis: A 1:20,000 dilution of this antibody was used to detected pro-Caspase 6 in MCF-7 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P55212 View All» Entrez Gene Number: NP_001217.2 View All» Gene Symbol:
  • CASP-6

  • MCH2

  • EC 3.4.22.59
    View All» Alternate Names:
    • Apoptotic protease Mch-2

    • caspase 6

    • caspase 6, apoptosis-related cysteine peptidase

    • caspase 6, apoptosis-related cysteine protease
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation

      • Flow Cytometry

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.CATALYTIC ACTIVITY: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.ENZYME REGULATION: Activation is suppressed by phosphorylation at Ser-257. Ref.5SUBUNIT STRUCTURE: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.SUBCELLULAR LOCATION: Cytoplasm. PTM: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.SEQUENCE SIMILARITY: Belongs to the peptidase C14A family. View All» Product Name: Anti-Caspase-6 (Pro), clone EP1325Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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