货号：04-1041

品牌：Merck Millipore

规格：

目录价：￥4376.00

市场价格：￥3719.60

会员价格：￥3500.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Musashi-1 (N-term) Antibody, clone EP1302, Rabbit | 04-1041 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Musashi-1 at and around the N-terminus. View All» Molecular Weight: ~39 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues on the N-terminus of human Musashi-1. View All» Clone: EP1302 View All» Isotype: IgG View All» Background Information: In mammals, the Musashi family is important for cell fate determination, playing roles in maintenance of the stem-cell state, differentiation and tumorigenesis. Musashi-1 (also known as Msi1), is selectivley expressed in neural progenitor cells, including neural stem cells. Outside the nervous system, Musashi-1 is a selective marker for intestinal stem or early lineage cells. Musashi-1 interacts with the Notch pathway during asymmetric cell division by binding the 3' UTR of Numb. Numb is prevented from repressing Notch signaling when Musashi-1 is present. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:50-100 dilution from a previous lot detected Musashi-1 in human brain tissue.Immunocytochemistry Analysis: A 1:250 - 500 dilution from a previous lot detected Musashi-1 in PC12 cells.Flow Cytometry: A 1:40 dilution of a previous lot was used in flow cytometry.Immunoprecipitation Analysis: A 1:50 dilution from a previous lot was used in IP. View All» Control: SHSY5Y cell lysate View All» Quality Assurance: Evaluated by Western Blot on SHSY5Y cell lysates.Western Blot Analysis: 1:2,000 dilution of this antibody was used to detect Musashi-1 in SHSY5Y cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: O43347 View All» Entrez Gene Number: NP_002433.1 View All» Gene Symbol: Musashi-1 View All» Alternate Names:
  • Musashi (Drosophila) homolog 1

  • musashi 1

  • musashi homolog 1 (Drosophila)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)

    • Flow Cytometry

    • Immunocytochemistry

    • Immunoprecipitation
      View All» Entrez Gene Summary: This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. View All» UniProt Summary: FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U1-3AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system By similarity.SUBCELLULAR LOCATION: Cytoplasm By similarity. Nucleus By similarity. TISSUE SPECIFICITY: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. DOMAIN: The first RNA recognition motif binds more strongly to RNA compared to the second one By similarity.SEQUENCE SIMILARITIES: Belongs to the Musashi family.Contains 2 RRM (RNA recognition motif) domains. View All» Product Name: Anti-Musashi-1 (N-term), clone EP1302, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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