货号：04-1037

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aurora-A (C-term) Antibody, clone EP1008Y, Rabbit | 04-1037 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Aurora-A at and around the C-terminus. View All» Molecular Weight: ~46 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the C-terminus of human Aurora-A. View All» Clone: EP1008Y View All» Isotype: Ig View All» Background Information: Aurora A, B, and C, are members of the serine/threonine kinase family. These have been identified as important regulators of the mitotic cell division process. Aurora B, specifically, is involved in the regulation of centrosome function, bipolar spindle assembly, and chromosome segregation. Overexpression of Aurora A can induce abnormalities in G2 and spindle checkpoints. This is seen in various tumors. View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Application Notes: Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected Aurora-A in human cervical carcionoma tissue.Immunoprecipitation: A 1:50 dilution from a previous lot was used in IP. View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot on HepG2 cell lysates.Western Blot Analysis: A 1:50,000 dilution of this antibody was used to detect Aurora-A in HepG2 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: O14965 View All» Entrez Gene Number: NP_003591.2 View All» Gene Symbol:

• AIK

• ARK1

• AURA

• AURORA2

• AurA

• Aurora-A

• BTAK

• EC 2.7.11.1

• MGC34538

• OTTHUMP00000031340

• OTTHUMP00000031342

• OTTHUMP00000031343

• OTTHUMP00000031344

• OTTHUMP00000031345

• OTTHUMP00000166071

• STK15

• STK6

• STK7

• hARK1
  View All» Alternate Names:
  • Aurora-related kinase 1

  • Aurora/IPL1-related kinase 1

  • Breast tumor-amplified kinase

  • IPL1-related kinase

  • Serine/threonine kinase 15

  • aurora kinase A

  • breast-tumor-amplified kinase

  • serine/threonine kinase 6

  • serine/threonine protein kinase 15

  • serine/threonine protein kinase 6

  • aurora/IPL1-like kinase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation
      View All» Entrez Gene Summary: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. May be involved in microtubule formation and/or stabilization. Phosphorylates ARHGEF2 and BORA.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.SUBUNIT STRUCTURE: Interacts with TACC1 and CPEB1. Interacts with its substrates BORA and ARHGEF2. SUBCELLULAR LOCATION: Centrosome. Spindle. Note: Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.TISSUE SPECFICITY: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. INVOLVEMENT IN DISEASE: Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain.Caution Although authors have considered STK6 and STK15 as two different proteins, it is clear that they are the same protein.SEQUENCE CAUTION: The sequence BAA23592.1 differs from that shown. Reason: Frameshift at positions 105, 125, 129, 235 and 241. View All» Product Name: Anti-Aurora-A (C-term), clone EP1008Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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