货号：MAB3434H

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Quanti-D Rh D Antigen Antibody, clone BTSN10, Phycoerythrin conjugated View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: PRINCIPLE This test is confined to use on maternal blood samples from Rh D negative women while pregnant or following delivery of Rh D positive babies. FMH during pregnancy may be caused by threatened miscarriage, chorionic villus sampling, placenta abruption, abdominal trauma or trauma induced by external cephalic version. FMH also may occur as a result of ectopic pregnancy, spontaneous abortion or termination of pregnancy. The test should be performed on maternal blood after any such event1. In addition, the magnitude of FMH should be estimated following delivery of Rh D positive infants1. The test should be carried out soon after the precipitating event or delivery in order to permit the timely administration of the appropriate amount of Rh D immunoglobulin to prevent alloimmunisation occurring in the mother. INTRODUCTION Currently, there is a world shortage of Rh D immunoglobulin for immunoprophylaxis. Administration of the appropriate dose is encouraged1 to ensure adequate protection against alloimmunisation while conserving a valuable resource. To determine the appropriate dose, it is necessary to quantitate the magnitude of a suspected FMH and administer Rh D immunoglobulin according to the extent of the foetal bleed. The required dose is estimated on the basis that 20mg of Rh D immunoglobulin will suppress immunisation by 1ml D-positive red cells (2ml foetal blood). Pack sizes for Rh D immunoglobulin vary. In Australia, 125μg is considered to be sufficient to suppress immunisation by up to 12ml of foetal blood1. Assuming a maternal blood volume of 5000ml, a haemorrhage of this magnitude would be detectable in the maternal circulation as approximately 0.25% of the red cell population or 1/400 cells. The use of flow cytometry to quantitate minor populations of Rh D positive cells has been explored by a number of workers2-5. The capacity of the flow cytometer to analyse a large number of cells in a short period of time enables accurate quantitation of FMH at clinically relevant levels. Quanti-Dä is designed for use with a flow cytometer. The test is simple to perform, rapid, reliable and objective. View All» Specificity: Recognises the Rh D antigen found on the red blood cells (RBC) of Rh D positive individuals. It will detect all normal strength homozygous and heterozygous expressions of D but may not detect D variants or weak D using this staining procedure. View All» Clone: BTSN10 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: This reagent is designed for the quantitation of Rh D positive RBC arising in the circulation of Rh D negative mothers as a consequence of foetomaternal haemorrhage (FMH). The procedure requires a single staining step followed by analysis using a flow cytometer. View All» Control: red blood cells (RBC) of Rh D positive individuals View All» Purification Method: Protein A purfied View All» Presentation: This product is supplied in phosphate buffered saline, pH 7.4, containing 0.1% sodium azide and 0.2% BSA. View All» Storage Conditions: Store at 2–8°C, for up to 6 months. DO NOT FREEZE. Protect from light. WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water. View All» UniProt Number: Q02161 View All» Entrez Gene Number: NM_016124.3 View All» Gene Symbol:

• RHD

• RhII

• RhK562-II

• Rh4

• Dpolypeptide

• RHDel

• RH30

• MGC165007

• RhDCw

• RHCED

• RH

• RHXIII

• RhPII

• DIIIc

• Rh30a

• RHDVA(TT)

• RHPII

• RhPI

• CD240D
  View All» Alternate Names: RH D View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. View All» UniProt Summary: FUNCTION: SwissProt: Q02161 # May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.SIZE: 417 amino acids; 45180 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Restricted to tissues or cell lines expressing erythroid characters.SIMILARITY: SwissProt: Q02161 ## Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Quanti-D Rh D Antigen Antibody, clone BTSN10, Phycoerythrin conjugated View All» Concentration: Ready to use View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 25 assays View All» Format: Phycoerythrin View All» Host: Mouse View All»
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