货号：MAB3418X

品牌：Merck Millipore

规格：100Ug

目录价：￥6895.00

市场价格：￥5860.75

会员价格：￥5516.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAP2 Antibody, Alexa Fluor® 488 conjugated | MAB3418X View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes MAP-2 (microtubule associated protein-2). MAP-2 is one of several high molecular weight proteins that play an important role in brain microtubule assembly. In addition to its association with microtubules, MAP-2 associates with neurofilaments and actin filaments suggesting that it may guide interaction among microtubules, other cytoskeletal elements, and cytoplasmic organelles (1). MAP-2 is a stringent marker for neurons. In addition, MAP-2 displays intracellular specificity. In the central nervous system, MAP-2 is confined to neuronal cell bodies and dendrites. There are exceptions, however, where some axons stain positive for small amounts of MAP-2 (2,3). MAP-2 is uniformly distributed throughout the cell when first expressed in cultured neurons but becomes selectively localized as dendritic development proceeds (4,5). SDS-PAGE Profiles: In SDS-PAGE MAP-2 from adult rat migrates as a closely associated doublet having a molecular weight of approximately 300 kD. However, early in brain development (postnatal day 10 in rats), MAP-2 migrates as a single band that is identical to the lower molecular weight band of the adult MAP-2 doublet (MAP-2b). Later in development (postnatal days 17-18), the mobility of MAP-2 changes to the adult doublet form. (In the spinal cord, conversion to the adult form occurs earlier). View All» Immunogen: Bovine brain microtubule protein. View All» Clone: AP20 View All» Isotype: IgG1 View All» Species Reactivity:

• Bovine

• Chicken

• Human

• Mouse

• Rat
  View All» Application Notes: Immunohistochemistry Optimal working dilutions must be determined by end user. APPLICATION NOTES: Immunohistochemistry: Anti-MAP-2 can be used to stain tissue (brain or spinal cord) fixed with paraformaldehyde. View All» Control: Brain, Neuronal culture, Human glioblastoma T98G cells View All» Purification Method: Protein A purfied View All» Presentation: Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide. View All» Storage Conditions: Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P11137 View All» Entrez Gene Number:
  • NM_001039538.1

  • NM_002374.3

  • NM_031845.2

  • NM_031847.2
    View All» Gene Symbol:
    • MAP2

    • MAP2B

    • MAP-2

    • MAP2C

    • DKFZp686I2148

    • MAP2A
      View All» Usage Statement:
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
        View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.SIZE: 1827 amino acids; 199539 Da PTM: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: P11137 ## Contains 3 Tau/MAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-MAP2 Antibody, Alexa Fluor® 488 conjugated | MAB3418X View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: All neurons, cytoplasmic, soma, dendritic View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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