货号：MAB3369

品牌：Merck Millipore

规格：1EA

目录价：￥5820.63

市场价格：￥4947.54

会员价格：￥4656.50

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-3 Antibody, clone SL-1 IID4 | MAB3369 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB3369 recognizes one doublet of 54kDa/59kDa and another doublet of 44kDa/49kDa, which are identified as unglycosylated and glycosylated species of pro (latent) and active forms of matrix metalloproteinase-3 (MMP-3; also known as Stromelysin-1 of Transin). MAB3369 shows no cross-reaction with the pro and active forms of other MMPs. CELLULAR LOCALIZATION: Cytoplasmic View All» Immunogen: APMA (4-Aminophenylmercuric acetate) activated Human stromelysin-1 View All» Clone: SL-1 IID4 View All» Isotype: IgG2b View All» Background Information: MMPs are frequently expressed in malignant neoplastic cells and play crucial roles in tumor invasion and metastasis. Tissue inhibitors of matrix metalloproteinases (TIMPs) control the activitiy of MMPS. The tissue distribution of three major MMPs has been defined in human mammary pathology: 1) collagenase (MMP-1) which degrades fibrillar interstitial collagens; 2) a 72-k/Da gelatinase (MMP-2) which mainly degrades type IV collagen and denatured collagens; and 3) stromelysin (MMP-3) which has a wider range of action, degrading several matrix components including the core proteins of proteoglycans, laminin and non-helical regions of collagens. View All» Species Reactivity: Human View All» Application Notes: Immunofluorescence Immunoprecipitation (Use Protein A): 2μg/ml protein lysate. Western blotting: 0.5-1.0 μg/ml for 2hrs at RT Immunohistology (frozen & formalin-fixed): 10-20 μg/ml for 60 minute at room temperature. No special pretreatment is required for staining of formalin-fixed, paraffin-embedded tissue sections. Optimal working dilutions and protocols must be determined by end user. View All» Control: POSTIVE CONTROL: Human endometrium cells, placenta, bladder, breast, ovarian carcinomas. View All» Presentation: Purified from ascites fluid by Protein A chromatography. 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. View All» Storage Conditions: Antibody with sodium azide is stable for 12 months when stored at 2-8°C. View All» UniProt Number: P08254 View All» Entrez Gene Number: NM_002422.3 View All» Gene Symbol:

• MMP3

• STR1

• Transin-1

• STMY

• MGC126102

• STMY1

• SL-1

• MGC126103

• MGC126104

• transin-1

• proteoglycanase

• MMP-3

• progelatinase

• EC 3.4.24.17
  View All» Alternate Names: Stromelysin-1; Transin; Proteoglycanase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunoprecipitation

  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P08254 # Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 477 amino acids; 53977 Da DOMAIN: SwissProt: P08254 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-3 Antibody, clone SL-1 IID4 | MAB3369 View All» Concentration: 200 μg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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