货号：03-188

品牌：Merck Millipore

规格：

目录价：￥6242.00

市场价格：￥5305.70

会员价格：￥4993.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: p300 (catalytic domain) human recombinant View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: Human recombinant p300 (catalytic domain) expressed in E. Coli View All» Background Information: Although originally termed histone acetyltransferases (HATs) for their lysine acetylation activity on histone N-terminal tails, p300 and its paralogue, CBP, have been shown to acetylate a variety of non-histone proteins including p53, DNA polymerase ß and nuclear import factors. p300/CBP acetylations play regulatory roles in transcription, DNA repair and replication, the cell cycle, p53 turnover, and nuclear import. In addition to functions which overlap with those of CBP, p300 has a number of unique functions, including a role in the induction of p21Waf1/Cip1 cell cycle inhibitor. View All» Key Applications: Enzyme Assay View All» Application Notes: Acetyltransferase assays View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Molecular Weight: ~52 kDa View All» Brand Family: Upstate View All» Source: Catalytic domain of huma p300 View All» Presentation: In liquid containing 50 mM Tris/HCl, pH 8.0, 0.1 mM EDTA, 10% glycerol View All» Storage Conditions: Stable for 12 months at -80ºC from date of receipt. Avoid multiple freeze/thaw cycles. View All» Product Name: p300 (catalytic domain) human recombinant View All» Physical Form: Frozen solution View All» Format: Purified View All» Host: E. coli View All» Specific Activity: >250 pmol/min/µg assayed as production of CoA-SH from AcCoA in the presence of a peptide comprising human p53 residues 368-386. CoA-SH is determined colorimetrically by reaction with DTNB (5,5′-Dithiobis (2-nitrobenzoic acid). View All» Purity: Purity >75% by SDS-PAGE View All»