货号：MAB3323

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-1 Antibody, active form only, N-Terminal domain, clone 195-1H6 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody specifically reacts with active form of hMMP-1, but not with precursor form of hMMP-1. The peptide used was (FVLTEGN, R81-87) of human interstitial collagenase (human MMP-1). SPECIES REACTIVITY: Does not cross-react with the precursor form of human MMP-1. View All» Epitope: active form only, N-Terminal domain, aa81-87 hMMP1 View All» Clone: 195-1H6 View All» Isotype: IgG2bκ View All» Species Reactivity: Human View All» Application Notes: Immunoblotting: use concentrated cell supernatants or extracts. Active MMP1 typically runs as a doublet 42-47kDa; note MMP1 has not been found in rodent species. View All» Presentation: Liquid in 0.1 M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P03956 View All» Entrez Gene Number: NM_002421.2 View All» Gene Symbol:

• MMP1

• CLG

• MMP-1

• CLGN

• EC 3.4.24.7 [Contains: 22 kDa interstitial collagenase

• 27 kDa interstitial collagenase].
  View All» Alternate Names: Interstitial Collagenase View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement:
  • Manufactured by Daiichi Fine Chemical Co., Ltd

  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P03956 # Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 469 amino acids; 54007 Da SUBUNIT: Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Secreted.DOMAIN: SwissProt: P03956 There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases). & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-1 Antibody, active form only, N-Terminal domain, clone 195-1H6 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-131010.htm
    © Merck Millipore代理MAB3323 MMP-1, ACTIVE, MSX-100UG;已停产，产品报价联系微信jinshanbio