货号：MAB3312

品牌：Merck Millipore

规格：EA

目录价：￥3920.00

市场价格：￥3332.00

会员价格：￥3136.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-3 Antibody, clone 148-1A3 | MAB3312 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody specifically reacts with the precursor and active forms of rabbit MMP-3. This is a purified mouse monoclonal antibody to rabbit matrix metalloproteinase 3 (rabbit MMP-3, stromelysin-1) from rabbit uterine cervical fibroblasts. SPECIES REACTIVITY: Does not cross-react with mouse and rat MMP-3, respectively. View All» Clone: 148-1A3 View All» Isotype: IgG1κ View All» Species Reactivity: Rabbit View All» Application Notes: Immunoblotting: 1:100-1:500 dilution, typically on concentrated cell supernatants or extracts. Immunohistochemistry on paraffin-embedded tissues: PLP fixation required. Fixation with traditional formalin fixation can be problematic. ElA: detection antibody View All» Presentation: Liquid in 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P08254 View All» Entrez Gene Number: NM_002422.3 View All» Gene Symbol:

• MMP3

• STR1

• Transin-1

• STMY

• MGC126102

• STMY1

• SL-1

• MGC126103

• MGC126104

• transin-1

• proteoglycanase

• MMP-3

• progelatinase

• EC 3.4.24.17
  View All» Alternate Names: Stromelysin-1; Transin; Proteoglycanase View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement:
  • Manufactured by Daiichi Fine Chemical Co., Ltd

  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P08254 # Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 477 amino acids; 53977 Da DOMAIN: SwissProt: P08254 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-3 Antibody, clone 148-1A3 | MAB3312 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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