货号：MAB3301

品牌：Merck Millipore

规格：1EA

目录价：￥4986.69

市场价格：￥4238.69

会员价格：￥3989.35

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TIMP-1 Antibody, clone 147-6D11 | MAB3301 View All» Replaces: MAB1338 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody specifically reacts with human TIMP-1. This is a purified mouse monoclonal antibody to recombinant human tissue inhibitor of metalloproteinases-1 (recombinant TIMP-1). SPECIES REACTIVITY: Does not cross-react with mouse and rat TIMP-1. View All» Immunogen: Mouse Mac-1 View All» Clone: 147-6D11 View All» Isotype: IgG1κ View All» Species Reactivity: Human Only View All» Application Notes: Immunoblotting: Suggested Dilution 1μg/mL Immunohistochemistry on paraffin-embedded tissue sections using PLP fixation; not tested on traditional formalin fixed tissues. Antigen retrieval is HIER methods ElA View All» Presentation: Liquid in 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P01033 View All» Entrez Gene Number: NM_003254.2 View All» Gene Symbol:

• TIMP1

• TIMP

• FLJ90373

• CLGI

• EPA

• EPO

• TIMP-1

• HCI
  View All» Alternate Names: Tissue Inhibitor of Metalloproteinase-1 View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. View All» UniProt Summary: FUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.SIZE: 207 amino acids; 23171 Da SUBCELLULAR LOCATION: Secreted.PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain. View All» Brand Family: Chemicon View All» Product Name: Anti-TIMP-1 Antibody, clone 147-6D11 | MAB3301 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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