货号：01-305

品牌：Merck Millipore

规格：

目录价：￥4364.00

市场价格：￥3709.40

会员价格：￥3491.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PDGF-BB, human View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Key Applications: Cell Culture View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P01127 # Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.SIZE: 241 amino acids; 27283 Da SUBUNIT: Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with XLKD1 (By similarity).SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.DISEASE: SwissProt: P01127 # A chromosomal aberration involving PDGFB is a cause of dermatofibrosarcoma protuberans (DFSP) [MIM:607907]. Translocation t(17;22)(q22;q13) with COLA1. DFSP is an uncommon, locally aggressive, but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It typically occurs during early or middle adult life and is most frequently located on the trunk and proximal extremities.SIMILARITY: SwissProt: P01127 ## Belongs to the PDGF/VEGF growth factor family.MISCELLANEOUS: A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. View All» Species: Human View All» Brand Family: Upstate View All» Source: Recombinant protein expressed in E.coli from the c-sis oncogene. View All» Presentation: Lypholized from 0.1M acetic acid View All» Gene Symbol:

• PDGFB

• FLJ12858

• PDGF2

• becaplermin

• SIS

• c-sis

• PDGF-2

• SSV

• Becaplermin
  View All» Product Name: PDGF-BB, human View All» Quality Assurance: Routinely evaluated by biological activity assay. View All» Physical Form: Lyophilized View All» UniProt Number: P01127 View All» Entrez Gene Number:
  • NM_002608.1

  • NM_033016.1
    View All» Purification Method: Sterilized through a 0.2 micron membrane filter View All»
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