货号：01-209

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: TGFβ1 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 µg View All» Key Applications: Cell Culture View All» Application Notes: ATP endpoint assay for cell number View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P01137 # Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodeling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.SIZE: 390 amino acids; 44341 Da SUBUNIT: The inactive form consists of a TGFB1 homodimer non- covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Highly expressed in bone.PTM: Glycosylated. & The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.DISEASE: SwissProt: P01137 # Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.SIMILARITY: SwissProt: P01137 ## Belongs to the TGF-beta family. View All» Species: Human View All» Brand Family: Upstate View All» Source: Recombinant human TGF-Beta 1 expressed in insect cells. View All» Presentation: Lypholized from sodium citrate, pH 3.5 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Gene Symbol:

• TGFB1

• TGFB

• DPD1

• CED

• TGF-beta-1
  View All» Product Name: TGFβ1 View All» Quality Assurance: Routinely evaluated in an ATP endpoint assay. View All» Physical Form: Lyophilized View All» UniProt Number: P01137 View All» Entrez Gene Number: NM_000660.3 View All» Purification Method: Sterilized through a 0.2 micron membrane filter View All»
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