货号：01-208

品牌：Merck Millipore

规格：

目录价：￥4652.00

市场价格：￥3954.20

会员价格：￥3721.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: IGF-I View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 25 µg View All» Background Information: Recombinant human IGF-I (Receptor Grade) expressed in E.coli. Human insulin-like growth factor-I (IGF-I) is a single chain 70 amino acid polypeptide that shares structural homology with insulin and human IGF-II. IGF-I plays a critical role in growth, differentiation and development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-I is a regulator of metabolism and is also implicated in the pathophysiology of cancer, diabetes and obesity. View All» Key Applications: Cell Culture View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972 [PubMed 4550398]). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986 [PubMed 3455760]; Rosenfeld, 2003 [PubMed 14657423]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P05019 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.| P01343 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.SIZE: 195 amino acids; 21841 Da SUBCELLULAR LOCATION: Secreted.DOMAIN: SwissProt: P05019 DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.| P01343 ## Belongs to the insulin family. View All» Species: Human View All» Brand Family: Upstate View All» Source: Recombinant human IGF-I expressed in E. coli. View All» Presentation: Lyophilized from 0.1M acetic acid View All» Gene Symbol:

• IGF1

• IBP1

• IGFI

• IGF-IA

• MGF

• IGF-IB
  View All» Product Name: IGF-I View All» Quality Assurance: Routinely evaluated in in chicken embryo fibroblasts over control cultures without IGF-I View All» Physical Form: Lyophilized View All» UniProt Number:
  • P05019

  • P01343
    View All» Entrez Gene Number: NM_000618.2 View All» Purification Method: Sterilized through a 0.2 micron membrane filter View All»
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