货号：01-201

品牌：Merck Millipore

规格：1EA

目录价：￥5464.68

市场价格：￥4644.98

会员价格：￥4371.74

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Heregulin-β3, EGF domain View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Key Applications: Cell Culture View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. View All» UniProt Summary: FUNCTION: SwissProt: Q15491 # The isoform SMDF may play a role in motor and sensory neuron development.| Q02297 # Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vessicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart.SIZE: 296 amino acids; 31686 Da SUBCELLULAR LOCATION: Secreted. Note=May possess an internal uncleaved signal sequence.TISSUE SPECIFICITY: Expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney.DEVELOPMENTAL STAGE: Highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons.DOMAIN: SwissProt: Q15491 DISEASE: SwissProt: Q02297 # A rare chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with ODZ4. The translocation fuses the 5'-end of ODZ4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.SIMILARITY: SwissProt: Q15491 ## Belongs to the neuregulin family. & Contains 1 EGF-like domain. | Q02297 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). & ERBB receptor binding is elicited entirely by the EGF-like domain.# Belongs to the neuregulin family. & Contains 1 EGF-like domain. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. View All» Brand Family: Upstate View All» Source: Thrombin cleaved GST-fusion protein corresponding to the EGF domain (residues 178-241) of heregulin-beta 3. View All» Presentation: PBS with 30% glycerol View All» Gene Symbol:

• NRG1

• NDF

• HRG

• Pro-NRG1

• HRGA

• HRG1

• SMDF

• GGF2

• HGL

• ARIA

• GGF
  View All» Product Name: Heregulin-β3, EGF domain View All» Quality Assurance: Routinely evaluated by Receptor Activation Analysis. View All» Physical Form: Liquid View All» UniProt Number:
  • Q1549

  • Q02297
    View All» Entrez Gene Number:
    • NM_004495.2

    • NM_013956.2

    • NM_013957.2

    • NM_013958.2

    • NM_013959.2

    • NM_013960.2

    • NM_013961.2

    • NM_013962.2

    • NM_013964.2
      View All» Purification Method: Sterilized through a 0.2 micron membrane filter View All»
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