货号：MAB3236

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytokeratin 18 Antibody, clone RCK106 | MAB3236 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Cytokeratin 18. MAB3236 reacts exclusively with human glandular epithelial cells of the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells as well as adenocarcinomas originating from them. SPECIES REACTIVITY: Human only. Does not react with other species. View All» Immunogen: Cytoskeletal preparation of human bladder carcinoma cell line T24. View All» Clone: RCK106 View All» Isotype: IgG1 View All» Background Information: Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight from between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8, The individual cytokeratin polypeptides are designated 1-20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. View All» Species Reactivity: Human Only View All» Application Notes: Western blot Immunohistochemistry on frozen and paraffin embedded tissue sections. Immunocytochemistry Flow cytometry Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid in buffer with 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P05783 View All» Entrez Gene Number:

• NM_000224.2

• NM_199187.1
  View All» Gene Symbol:
  • KRT18

  • K18

  • Keratin-18

  • CYK18

  • Cytokeratin-18

  • CK-18
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P05783 # Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.SIZE: 430 amino acids; 48058 Da SUBUNIT: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin- antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.SUBCELLULAR LOCATION: Cytoplasm, perinuclear region.TISSUE SPECIFICITY: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.PTM: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. & Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.DISEASE:SwissProt: P05783 # Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].SIMILARITY: SwissProt: P05783 ## Belongs to the intermediate filament family.MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). View All» Brand Family: Chemicon View All» Product Name: Anti-Cytokeratin 18 Antibody, clone RCK106 | MAB3236 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Target / Localization: General marker for proliferating malignant epithelial cells, including breast, ovarian, lung, prostatic, bladder & gastrointestinal View All» Format: Purified View All» Host: Mouse View All»
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