货号：MAB319

品牌：Merck Millipore

规格：

目录价：￥4239.00

市场价格：￥3603.15

会员价格：￥3391.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Chromogranin A Antibody, clone PHE5 | MAB319 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Chromogranin A. The antibody has been extensively documented on immunohistochemical studies in deparaffinized methacarn fixed tissue, where it is a sensitive marker of neuroendocrine cells and tumors. Not recommended for formalin fixed tissues, see MAB5268 or CBL219. On western blots, it identifies the identical bands recognized by antibody LK2H10 (Wilson and Lloyd). View All» Immunogen: Human pheochromocytoma View All» Clone: PHE5 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Monkey
  View All» Non-Reactive Species:
  • Mouse

  • Rat
    View All» Application Notes: Immunohistochemistry: 1:500-1:2,000 on alcohol fixed deparaffinized tissue sections (ABC peroxidase) or 1:10,000 on Methacarn-fixed deparaffinized tissue sections. Will show fine granular cytoplasmic staining associated with secretory granules. Western Blot: recognizes a band migrating at approximately 68-75 kDa corresponding to chromogranin A. Optimal working dilutions must be determined by the end user. View All» Control: POSOTIVE CONTROL: Normal adrenal gland, bowel, or thyroid tissue. View All» Presentation: Liquid in 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P10645 View All» Entrez Gene Number: NM_001275.3 View All» Gene Symbol:
    • CHGA

    • CgA

    • SP-I

    • CGA
      View All» Alternate Names: CgA; Pituitary Secretory Protein I View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. View All» UniProt Summary: FUNCTION: SwissProt: P10645 # Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.SIZE: 457 amino acids; 50730 Da SUBCELLULAR LOCATION: Secreted. Note=Neuroendocrine and endocrine secretory granules.PTM: Sulfated on tyrosine residues and/or contains sulfated glycans.SIMILARITY: SwissProt: P10645 ## Belongs to the chromogranin/secretogranin protein family. MISCELLANEOUS: Binds calcium with a low-affinity. View All» Brand Family: Chemicon View All» Product Name: Anti-Chromogranin A Antibody, clone PHE5 | MAB319 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Peripheral, Neuroendocrine, presynaptic View All» Format: Purified View All» Host: Mouse View All»
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