货号：MAB3132

品牌：Merck Millipore

规格：200Ug

目录价：￥6895.00

市场价格：￥5860.75

会员价格：￥5516.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Surfactant Protein D Antibody, lectin domain, clone IVF11 | MAB3132 View All» Replaces: MAB3130 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB3132 recognizes an epitope localized in the lectin domain of rat surfactant protein D (SP-D). Reacts with alveolar type II cells, alveolar macrophages, types of Clara cells (in which SpD is highly concentrated), SP-A+ and SP-A-, and extracellular deposits. Alveolar type III cells are negative. No reaction on rat skin, colon, kidney or liver. SP-A cross reacitivity is typically evident at very low dilutions (1 to less than a few hundred) by ELISA. View All» Epitope: lectin domain View All» Immunogen: Purified rat surfactant protein D from bronchoalveolar lavage. View All» Clone: IVF11 View All» Isotype: IgG1κ View All» Background Information: Surfactant protein D is a Ca2+ dependent carbohydrate binding protein with a structure similar to other C-type mammalian lectins. Its molecular weight is 620 kDa under non-reducing conditions and 43 kDa under reducing conditions. The function of SP-D is not clearly defined. SP-D enhances the production of oxygen radicals in alveolar macrophages and regulates some actions of SP-A. View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry on snap frozen or paraffin embedded tissue. Suggested working dilution for fresh rat tissue is 1:400 and for fresh human tissue is 1:20. Fixation: acetone 5 min at 4°C, paraformaldehyde, paraffin. Tissue pretreatment: microwave treatment 2 x 5 min at 750 W for paraffin tissues. Western blot ELISA: as capture antibody Optimal working dilutions must be determined by the end user. View All» Presentation: Immunoglobulin purified from tissue culture supernatant. Lyophilized from buffer containing 5 mg/mL BSA and 0.09% sodium azide. View All» Storage Conditions: Maintain lyophilized material at 2-8°C for up to 12 months from date of receipt. Reconstitute lyophilized material with 500 μL of sterile distilled water. After reconstitution, maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P35247 View All» Entrez Gene Number: NM_003019.4 View All» Gene Symbol:
  • SFTPD

  • SP-D

  • SFTP4

  • PSPD

  • PSP-D

  • COLEC7
    View All» Alternate Names: SP-D View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P35247 # Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.SIZE: 375 amino acids; 37698 Da SUBUNIT: Oligomeric complex of 4 set of homotrimers.SUBCELLULAR LOCATION: Secreted, extracellular space.PTM: The N-terminus is blocked. & Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates (By similarity).SIMILARITY: SwissProt: P35247 ## Contains 1 C-type lectin domain. & Contains 1 collagen-like domain. MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C)." View All» Brand Family: Chemicon View All» Product Name: Anti-Surfactant Protein D Antibody, lectin domain, clone IVF11 | MAB3132 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Target / Localization: All pulmonary airways, Type II alveolar, nonciliated airway epithelial cells, Clara cells, tracheal & bronchial glands; many mucosal surfaces in various organs View All» Format: Purified View All» Host: Mouse View All»
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