货号：MAB3060

品牌：Merck Millipore

规格：100Ug

目录价：￥7355.00

市场价格：￥6251.75

会员价格：￥5884.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Paxillin Antibody, clone 349 | MAB3060 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts strongly with two bands on Western blots of total cell lysate from chick embryo fibroblasts or rat brain. The lower molecular band is believed to be either an isoform or a degradation product of the 68 kD protein, since it is found also on SDS-PAGE of affinity-purified paxillin. View All» Immunogen: Affinity purified phosphotyrosine-containing proteins from Rous sarcoma virus-transformed chick embryo fibroblasts. View All» Clone: 349 View All» Isotype: IgG1 View All» Species Reactivity:

• Canine

• Chicken

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:1,000-1:10,000 ELISA Immunohistochemistry 1:900 in Placenta Immunocytochemistry Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: For western blot, load 5-10 μg of whole cell lysate prepared from the human epidermoid carcinoma cell line, A431. View All» Presentation: Purified immunoglobulin. Liquid in aqueous buffered solution containing 0.09% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. View All» UniProt Number: P49023 View All» Entrez Gene Number: NM_002859.1 View All» Gene Symbol:
  • PXN

  • Paxillin.

  • paxillin

  • FLJ16691
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: SwissProt: P49023 # Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).SIZE: 591 amino acids; 64533 Da SUBUNIT: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.SIMILARITY: SwissProt: P49023 ## Belongs to the paxillin family. & Contains 4 LIM zinc-binding domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Paxillin Antibody, clone 349 | MAB3060 View All» Concentration: 1.05 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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