货号：MAB2643

品牌：Merck Millipore

规格：EA

目录价：￥3696.00

市场价格：￥3141.60

会员价格：￥2956.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fibrillin-3 Antibody, clone 129 | MAB2643 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes Fibrillin-3. View All» Molecular Weight: ~ 300 kDa View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to human Fibrillin-3. View All» Isotype: IgG1κ View All» Background Information: Fibrillin-3 is a recently described part of the Fibrillin family of glycoproteins, which are essential factors in the formation and maintenance of elastic fibers known as microfibrils within the extracellular matrix. It is very similar in organization and function to Fibrillin-1 and Fibrillin-2. Localization of Fibrillin-3 has been found in cultured skin fibroblasts along with several other cell and tissue types. Highest expression has been noted in brain, fetal lung and kidney with significantly smaller signals seen in throughout adult tissues. (Corson, 2004). View All» Species Reactivity:

• Human

• Bovine

• Chicken
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with bovine and chicken based on 100% sequence homology. View All» Application Notes: ELISA Analysis: A previous lot was used by an independent laboratory in ELISA. (Corson, 2004).Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Corson, 2004). View All» Control: Muscle fiber tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in muscle fiber paraffin-embedded tissue sections..Immunohistochemistry Analysis: 1:100 dilution of this antibody detected Fibrillin-3 in paraffin-embedded tissue sections of muscle fiber tissue. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q75N90 View All» Entrez Gene Number: NP_115823 View All» Gene Symbol: FBN3 View All» Alternate Names:
  • fibrillin 3

  • fibrillin-3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • ELISA

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene encodes a protein that belongs to the fibrillin gene family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. While several transcript variants may exist for this gene, their full-length natures have not been described to date. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support. SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix TISSUE SPECIFICITY: Predominantly expressed in connective tissues such as skeletal muscle, tendon, skin, perichondrium and periosteum. Highly expressed in fetal lung, brain, kidney. Expressed at low level in prostate, testis, mammary gland, uterus, ovary, placenta, bladder, adrenal gland, thyroid, fetal thymus, fetal liver, liver, fetal heart and heart. PTM: Probably forms intermolecular disulfide bonds either with other FBN3 molecules or with other components of the microfibrils (by similarity).SEQUENCE SIMILARITIES: Belongs to the fibrillin family.Contains 44 EGF-like domains.Contains 9 TB (TGF-beta binding) domains. View All» Product Name: Anti-Fibrillin-3, clone 129 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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