货号：MAB2625

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-XB130 Antibody, clone 12 | MAB2625 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes XB130. View All» Molecular Weight: The calculated MW is ~ 91 kDa. However, it is usually observed as 110-130 kDa. View All» Epitope: Unknown View All» Immunogen: His-tagged full length recombinant protein corresponding to human XB130. View All» Clone: 12 View All» Isotype: IgG2aκ View All» Background Information: XB130 is a 130 kDa adaptor protein and Src kinase substrate, structurally similar to actin-filament-associated protein. Recent evidence indicates tyrosine 54 of XB130 as the major target of RET/PTC-mediated phosphorylation and a critical binding site for the SH2 domains of p85alpha. Importantly, downregulation of XB130 in TPC1 papillary thyroid cancer cells, harboring the RET/PTC1 kinase, strongly reduced Akt activity without altering ERK1/2 phosphorylation, and concomitantly inhibited cell-cycle progression and survival in suspension. XB130 is a novel substrate of the RET/PTC kinase that links RET/PTC signaling to PI 3-kinase activation, and thereby plays an important role in sustaining proliferation and survival of thyroid tumor cells, (Lodyga, 2009). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: A549 cell lysate View All» Quality Assurance: Evaluated by Western Blot on A549 cell lysate.Western Blot Analysis: 0.1 µg/ml of this antibody detected XB130 on 10 µg of A549 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8N4X5 View All» Entrez Gene Number: NP_115939.1 View All» Gene Symbol:

• XB130

• AFAP1L2

• KIAA1914
  View All» Alternate Names:
  • Actin filament associated protein 1-like 2

  • AFAP1-like protein 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Immunocytochemistry

    • ELISA

    • Enzyme Assay
      View All» UniProt Summary: FUNCTION: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. SUBUNIT STRUCTURE: Interacts with SRC. Interacts with LCK when tyrosine phosphorylated. SUBCELLULAR LOCATION: Cytoplasm TISSUE SPECIFICITY: Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas.PTM: Tyrosine phosphorylated (by SRC). SEQUENCE SIMILARITIES: Contains 2 PH domains. View All» Product Name: Anti-XB130, clone 12 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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