货号：MAB2259

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7 | MAB2259 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes cholesterol-24 hydroxylase. View All» Molecular Weight: ~ 54 kDa View All» Epitope: unknown View All» Immunogen: His-tagged recombinant protein corresponding to human cholesterol-24 hydroxylase. View All» Clone: 1A7 View All» Isotype: IgG1κ View All» Background Information: In enzymology, a cholesterol 24-hydroxylase (EC 1.14.13.98) is an enzyme that catalyzes the chemical reaction:cholesterol + NADPH + H+ + O2 --> (24S)-24-hydroxycholesterol + NADP+ + H2O. Cholesterol 24-hydroxylase, a cytochrome P450 (CYP46A1), is expressed at 100-fold higher levels in the brain than in the liver. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. Studies indicate that cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain (Lund, 2003). View All» Species Reactivity:

• Mouse

• Human

• Rat

• Rabbit
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with human, rat, and rabbit based on 100% sequence homology. View All» Control: Mouse brain lysate View All» Quality Assurance: Evaluated by Western Blot in Cholesterol-24 hydroxylase mouse brain lysate.Western Blot Analysis: 1 µg/ml of this antibody detected Cholesterol-24 hydroxylase on 10 µg of Cholesterol-24 hydroxylase mouse brain lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y6A2 View All» Entrez Gene Number: NP_006659 View All» Gene Symbol:
  • CH24H

  • CP46

  • CYP46

  • CYP46A1
    View All» Alternate Names:
    • Cytochrome P450 46A1

    • cholesterol 24-hydroxylase

    • cytochrome P450, family 46

    • cytochrome P450, family 46, subfamily A, polypeptide 1

    • cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.CATALYTIC ACTIVITY: Cholesterol + NADPH + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O.COFACTOR: Heme group By similarity.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. TISSUE SPECIFICTY: Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.SEQUENCE SIMILARITIES: Belongs to the cytochrome P450 family.BIOPHYSICOCHEMICAL PROPERTIEIS: Kinetic parameters:KM=2.2 µM for 24(S)-hydroxycholesterol View All» Product Name: Anti-Cholesterol-24 Hydroxylase, clone 1A7 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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