货号：MAB2235

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GCAP2 Antibody, clone A1 | MAB2235 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GCAP2. View All» Molecular Weight: ~23 kDa View All» Epitope: N/A View All» Immunogen: GST-tagged GCAP2. View All» Clone: A1 View All» Isotype: IgG2aκ View All» Background Information: Guanylate cyclase-activating proteins (GCAPs) are calcium binding proteins that belong to the calmodulin super family. GCAPs without calcium are responsible for activation of photoreceptor guanylate cyclase during light adaptation. Studies have shown that the addition or subtraction of Ca2+ results in major conformational changes and the activation/deactivation of GCAP 1 and GCAP 2. It has been demonstrated that both GCAP 1 and 2 act on guanylate cyclase similarly and have approximately 50% homology between the two forms. GCAP 1 is predominantly localized in the photoreceptor outer segments. These results suggest that although GCAP1 is involved in the Ca2+-sensitive regulation of GC in rod and cone outer segments, GCAP2 may have non-phototransduction functions in photoreceptors and inner retinal neurons. View All» Species Reactivity: Bovine View All» Species Reactivity Note: Bovine. Reactivity with other species has not been tested. View All» Application Notes: Immunohistochemistry: 1:2,000 was tested on monkey retina (See reference 1). Working dilutions should be optimized by end user. View All» Control: Bovine Retina Lysate. View All» Quality Assurance: Western Blot Analysis: 1:2,000 dilution of this lot detected GCAP2 on 10 µg of Bovine Retina lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2aқ in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q9UMX6 View All» Entrez Gene Number: NP_002089.4 View All» Gene Symbol:

• DKFZp686E1183

• GCAP2

• GUCA2

• OTTHUMP00000016398

• OTTHUMP00000039781
  View All» Alternate Names:
  • GCAP 2

  • Guanylate cyclase activator 1B

  • guanylate cyclase activator 1B (retina)

  • guanylate cyclase-activating protein 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION:Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.SUBCELLULAR LOCATION: Cell membrane. Note= Membranes of outer segment.TISSUE SPECIFICITY: Retina. Cones and rod.MISCELLANEOUS: Binds three calcium ions By similarity.SIMILARITY: Contains 4 EF-hand domains. View All» Product Name: Anti-GCAP2 Antibody, clone A1 | MAB2235 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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