货号：MAB2230

品牌：Merck Millipore

规格：EA

目录价：￥3708.00

市场价格：￥3151.80

会员价格：￥2966.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RGS9-1 Antibody, clone D | MAB2230 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RGS9-1. View All» Molecular Weight: Approx. 57 kDa View All» Immunogen: This antibody is generated using recombinant mouse RGS9-1. View All» Clone: D7 View All» Isotype: IgG2bκ View All» Background Information: Regulator of G-protein signaling 9 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. It is involved in phototransduction, key element in the recovery phase of visual transduction. View All» Species Reactivity: Bovine View All» Species Reactivity Note: Proven to react with bovine. It has not been tested in other animals. View All» Control: Bovine retina cell lysate View All» Quality Assurance: Evaluated by Western Blot in bovine retina cell lysate.Western Blot Analysis: : 1 µg/mL dilution of this antibody detected RGS9-1 on 15 µg of bovine retinal lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified monoclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for 1 year from date of receipt. View All» UniProt Number: O54828 View All» Entrez Gene Number: NP_035398.2 View All» Gene Symbol:

• MGC111763

• MGC26458

• PERRS

• RGS9L
  View All» Alternate Names:
  • regulator of G protein signalling 9

  • regulator of G protein signalling 9L

  • regulator of G-protein signaling 9

  • regulator of G-protein signaling 9L

  • regulator of G-protein signalling 9
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction By similarity.SUBUNIT STRUCTURE: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of isoform 3 of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP Probable.SUBCELLULAR LOCATION: Isoform 3: Membrane; Peripheral membrane protein. Note: Isoform 3 is targeted to the membrane via its interaction with RGS9BP By similarity.TISSUE SPECIFICITY: Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).DOMAIN: In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments. PTM: Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition By similarity.INVOLVEMENT IN DISEASE: Defects in RGS9 are a cause of prolonged electroretinal response suppression (PERRS) [MIM:608415]; also known as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. SEQUENCE SIMILARITIES: Contains 1 DEP domain.Contains 1 G protein gamma domain.Contains 1 RGS domain. View All» Product Name: Anti-RGS9-1, clone D7 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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