货号：MAB2226

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Piccolo Antibody, clone 4G3.3 | MAB2226 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes piccolo. View All» Molecular Weight: 547 kDa View All» Immunogen: GST-tagged recombinant protein View All» Clone: 4G3.3 View All» Isotype: IgMκ View All» Background Information: Piccolo (presynaptic cytomatrix protein or PCLO) may act as a scaffolding protein involved in the organization of synaptic active zones. Synaptic vesicles dock and fuse in the active zone of the plasma membrane at chemical synapses. The presynaptic cytoskeletal matrix (PCM), which is associated with the active zone and is situated between synaptic vesicles, is thought to be involved in maintaining the neurotransmitter release site in register with the postsynaptic reception apparatus. The cycling of synaptic vesicles is a multistep process involving a number of proteins. Among the components of the PCM that orchestrate these events are Bassoon (BSN), RIM (RBBP8), Oboe, and Piccolo (PCLO) [supplied by ENTREZGENE]. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Mouse and Rat.Predicted to react with human based on 82% sequence homology and rat based on 92% sequence homology. View All» Application Notes: Immunohistochemistry (Paraffin):Representative images from a previous lot.Piccolo staining pattern/morphology on mouse brain tissue/cerebellum. Tissue was pretreated with citrate pH 6.0, antigen retrieval. A previous lot of the antibody was diluted to 1:300, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is localized to the synaptic junction of neurons in the granular layer and Purkinje cells(arrow). View All» Control: Rat brain lysate, mouse cerebellum View All» Quality Assurance: Routinely evaluated by western blot on rat brain lysate. View All» Purification Method: Ammonium sulfate precipitation View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y6V0 View All» Entrez Gene Number: NP_001104266 View All» Gene Symbol:
  • ACZ

  • Aczonin

  • DKFZp779G1236

  • KIAA0559
    View All» Alternate Names:
    • presynaptic cytomatrix protein

    • Aczonin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking (By similarity). SUBUNIT: Interacts with Rabac1/Pra1, RIMS2 and profilin (By similarity). SUBCELLULAR LOCATION: Cell junction, synapse (By similarity). Note=Concentrated at the presynaptic side of synaptic junctions (By similarity). ALTERNATIVE PRODUCTS: 3 named isoforms DOMAIN: C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change. SIMILARITY: Contains 2 C2 domains. SIMILARITY: Contains 1 PDZ (DHR) domain. SEQUENCE CAUTION: Sequence=AAD21789.2; Type=Erroneous gene model prediction; View All» Product Name: Anti-Piccolo Antibody, clone 4G3.3 | MAB2226 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-130617.htm
        © Merck Millipore代理MAB2226 Anti-Piccolo Antibody, clone 4G3.3;store at +2℃ to +8℃，产品报价联系微信jinshanbio