货号：MAB2154

品牌：Merck Millipore

规格：100Ug

目录价：￥5887.00

市场价格：￥5003.95

会员价格：￥4709.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-P-Selectin Antibody, clone P8G6 | MAB2154 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human P Selectin View All» Immunogen: IL-1beta activated HUVEC (human) View All» Clone: P8G6 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue Immunocytochemistry Immunoprecipitation ELISA Inhibits P Selectin dependent interactions Inhibits platelet binding to monocytes Optimal working dilutions must be determined by end user. View All» Presentation: Purified in 0.02M PBS, 0.25M NaCl, pH 7.6 with 0.1% NaN3. Liquid View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: Q14242 View All» Entrez Gene Number: NM_003006.3 View All» Gene Symbol:

• SELPLG

• CLA

• PSGL-1

• CD162

• PSGL1
  View All» Alternate Names: CD62P; Granule Membrane Protein-140; GMP-140; Platelet Activation Dependent Granule-external Membrane Protein; PADGEM View All» Sales Restrictions: This product is not available for sale in the United States. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunoprecipitation

  • Immunocytochemistry

  • Immunohistochemistry

  • Affects Function
    View All» Entrez Gene Summary: SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. View All» UniProt Summary: FUNCTION: SwissProt: Q14242 # Binds to P-, E- and L-selectins. The calcium-dependent high affinity interaction with P-selectin mediates the tethering and rolling of neutrophils and T-lymphocytes on endothelial cells.SIZE: 412 amino acids; 43201 Da SUBUNIT: Homodimer; disulfide-linked.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed on neutrophils, monocytes and most lymphocytes.PTM: Displays complex, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N- acetyllactosamine with varying degrees of substitution. Also N- glycosylated. & Sulfated in the N-terminal region; sulfation is necessary for P-selectin binding. View All» Brand Family: Chemicon View All» Product Name: Anti-P-Selectin Antibody, clone P8G6 | MAB2154 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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