货号：MAB2144

品牌：Merck Millipore

规格：100Ug

目录价：￥4858.00

市场价格：￥4129.30

会员价格：￥3886.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VCAM-1 Antibody, clone P3C4 | MAB2144 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human VCAM View All» Molecular Weight: 81 kDa View All» Immunogen: IL-1beta activated HUVEC (human) View All» Clone: P3C4 View All» Isotype: IgG1 View All» Background Information: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. View All» Species Reactivity: Human View All» Species Reactivity Note: Reacts with human. Other species have not been tested. View All» Application Notes: Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue Immunocytochemistry: for use on HUT 78 and endothelial cells activated with cytokines. VCAM is also expressed on skeletal muscle. Immunoprecipitation Flow cytometry ELISA Inhibits cell adhesion to IL-1beta1 activated HUVEC Optimal working dilutions must be determined by end user. View All» Control: Immunohistochemistry: Angiogenesis producing cancers or vascular tissue. View All» Quality Assurance: Routinely evaluated by immunohistochemistry on ovarian cancer tissue. View All» Purification Method: Protein G purfied View All» Presentation: Nonsterile liquid contains 0.02M phosphate buffer, 0.25M sodium chloride, and 0.1% sodium azide. Filtered through 0.45 micron membrane filter. View All» Storage Conditions: Maintain at +2-8°C. View All» UniProt Number: P19320 View All» Entrez Gene Number:

• NM_001078.2

• NM_080682.1
  View All» Gene Symbol:
  • VCAM1

  • INCAM-100

  • MGC99561

  • CD106

  • DKFZp779G2333

  • L1CAM
    View All» Alternate Names: CD106 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Flow Cytometry

    • Immunoprecipitation

    • Immunocytochemistry

    • Immunohistochemistry

    • Affects Function
      View All» Entrez Gene Summary: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P19320 # Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.SIZE: 739 amino acids; 81276 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.DOMAIN: SwissProt: P19320 Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.PTM: Sialoglycoprotein.DISEASE:SwissProt: P19320 # May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-VCAM-1 Antibody, clone P3C4 | MAB2144 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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