货号：MAB2137

品牌：Merck Millipore

规格：100Ug

目录价：￥5887.00

市场价格：￥5003.95

会员价格：￥4709.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Homing Receptor Antibody, clone A020 | MAB2137 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Antibody reacts with the standard CD44 isoform (CD44s) that lacks exon sequences v1-v10. Also called human CD44 (85-95 kDa) gp90{Hermes} and mouse gp85 (Pgp-1). View All» Molecular Weight: 90 kDa View All» Immunogen: Purified human blood lymphocyte CD44 View All» Clone: A020 View All» Isotype: IgG2b View All» Species Reactivity:

• Bovine

• Canine

• Human

• Mouse

• Pig

• Rat

• Rabbit
  View All» Application Notes: ELISA 1:2000 Flow Cytometry :1:1000 Immunofluorescence 1:200 Immunohistostaining of paraffin embedded tissues. 1:250; antigen retrieval is usually not needed. Immunoprecipitation 1:200 Western blotting: non-reduced conditions only; 90kDa band is detected; blocking PBS/5% milk protein, primary antibody dilution 1:1000 o/n incubation. Optimal working dilutions must be determined by end user. View All» Control: Cells of epithelium and highly expressed by carcinomas View All» Purification Method: Protein A purfied View All» Presentation: Liquid in 10 mM sodium phosphate, pH 7.5 with 150 mM NaCl and 0.01% sodium azide. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P16070 View All» Entrez Gene Number:
  • NM_000610.3

  • NM_001001389.1

  • NM_001001390.1

  • NM_001001391.1

  • NM_001001392.1
    View All» Gene Symbol:
    • CD44

    • LHR

    • HUTCH-I

    • CDW44

    • CDw44

    • ECMR-III

    • Epican

    • MGC10468

    • CD44R

    • PGP-1

    • MDU2

    • CSPG8

    • Pgp1

    • IN

    • MUTCH-I

    • MIC4

    • MDU3

    • MC56

    • HCELL
      View All» Alternate Names: CD44s; HCAM; Pgp-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Flow Cytometry

      • Immunocytochemistry

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. View All» UniProt Summary: FUNCTION: SwissProt: P16070 # Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.SIZE: 742 amino acids; 81554 Da SUBUNIT: Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.PTM: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. & N-glycosylated. & O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). & Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.SIMILARITY: SwissProt: P16070 ## Contains 1 Link domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Homing Receptor Antibody, clone A020 | MAB2137 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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