货号：MAB2087

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mouse Anti-αT-Catenin Antibody, amino acids 164-177, clone 892_24D2S View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with alphaT-catenin does not show any cross reaction with alphaE-catenin or alphaN-catenin in western blot analysis. View All» Epitope: amino acids 164-177 View All» Immunogen: Synthetic peptide corresponding to amino acids 164-177 of human alphaT-catenin protein coupled to KLH. View All» Clone: 892_24D2S View All» Isotype: IgG2a View All» Background Information: Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human alphaT-catenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It is proven that alphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha catenins. This indicates that this protein is involved in the formation of specific cell-cell contacts in specific types of muscle cells. The encoded protein has about the same predicted size (100 kDa) as other alpha catenins to which it shows an overall amino acid identity of 57%. In cells transfected with alphaT-catenin cDNA, interaction with beta catenin was demonstrated by coimmunoprecipitation. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:100 - 1:1000 Immunohistochemistry: 1:25 - 1:200; Frozen or paraffin-embedded tissue sections with avidin-biotinylated horseradish peroxidase complex (ABC) as detection method. Immunocytochemistry: Methanol and paraformaldehyde-fixed cells followed by permeablization with 0.2% Triton-X 100 for 2 minutes Immunofluorescence: Acetone-fixed cells Immunoprecipitation Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide. View All» Storage Conditions: Maintain at 2°-8°C for up to 12 months from date of receipt. View All» UniProt Number: P35221 View All» Entrez Gene Number: NM_001903.2 View All» Gene Symbol:

• CTNNA1

• FLJ36832

• alpha-E-catenin

• CAP102

• alpha-catenin

• alphaE-catenin
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunofluorescence

  • Immunoprecipitation

  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» UniProt Summary: FUNCTION: SwissProt: P35221 # Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.SIZE: 906 amino acids; 100071 Da SUBUNIT: Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, adherens junction; Cytoplasmic side. Cell junction; Cytoplasmic side. Note=Found at cell-cell boundaries and probably at cell- matrix boundaries.TISSUE SPECIFICITY: Expressed ubiquitously in normal tissues.PTM: Sumoylated.DISEASE:SwissProt: P35221 # Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.SIMILARITY: SwissProt: P35221 ## Belongs to the vinculin/alpha-catenin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Mouse Anti-αT-Catenin Antibody, amino acids 164-177, clone 892_24D2S View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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