货号：MAB2083

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-γ-Catenin Antibody, clone 11E4 | MAB2083 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Produced by immunization with recombinant human G-catenin. View All» Clone: 11E4 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: Histochoice fixative is effective. Immunocytochemistry: Effective for A431 and HT1080 cell lines. Immunoblotting Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Presentation: Liquid at 1 mg/mL in 0.02 M phosphate buffer, pH 7.6, 0.25M NaCl, containing 0.1% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to12 months. View All» UniProt Number: P14923 View All» Entrez Gene Number:

• NM_002230.1

• NM_021991.1
  View All» Gene Symbol:
  • JUP

  • PKGB

  • CTNNG

  • ARVD12

  • PDGB

  • gamma-catenin

  • DP3

  • DPIII

  • Desmoplakin-3
    View All» Alternate Names: Plakoglobin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. View All» UniProt Summary: FUNCTION: SwissProt: P14923 # Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.SIZE: 744 amino acids; 81630 Da SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane- associated form.DISEASE: SwissProt: P14923 # Defects in JUP are the cause of Naxos disease [MIM:601214]. Naxos disease is an autosomal recessive disorder combining non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular cardiomyopathy and woolly hair.SIMILARITY: SwissProt: P14923 ## Belongs to the beta-catenin family. & Contains 8 ARM repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-γ-Catenin Antibody, clone 11E4 | MAB2083 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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