货号：07-2268

品牌：Merck Millipore

规格：

目录价：￥3821.00

市场价格：￥3247.85

会员价格：￥3056.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-TBC1D1 (Ser237) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes TBC1D1 phosphorylated at Ser237. View All» Molecular Weight: ~145 kDa observed View All» Epitope: Phosphorylated Ser237 View All» Immunogen: KLH-conjugated linear peptide corresponding to human TBC1D1 phosphorylated at Ser237. View All» Modifications: Phosphorylation View All» Background Information: TBC1D1 is the first member of a family of proteins that contain the tbc box motif of 180-220 amino acids and may be related to cell growth and differentiation. The composition of TBC1D1 has the same function as a known regulator of insulin-mediated Glut4 translocation and may play a role in severe human obesity. An insulin-independent increase in glucose transport several hours after exercise has been attributed to TBC1D1 phosphorylation. The R125W mutation of TBC1D1 is thought to decrease skeletal muscle glucose transport and could be the main reason for the obesity that seems to be linked to this type of mutation. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chimpanzee

• Rhesus Macaque

• Ox
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, chimpanzee, rhesus macaque, and ox based on 100% sequence homology. View All» Control: Lambda phosphatase treated and untreated HEK293 cell lysates View All» Quality Assurance: Evaluated by Western Blot in lambda phosphatase treated and untreated HEK293 cell lysates.Western Blot Analysis: 1 µg/mL of this antibody detected TBC1D1 on 10 µg of lambda phosphatase treated and untreated HEK293 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q86TI0 View All» Entrez Gene Number: NP_055988 View All» Gene Symbol:
  • TBC1D1

  • TBC

  • TBC1
    View All» Alternate Names:
    • TBC1 domain family member 1

    • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). SEQUENCE SIMILARITIES: Contains 1 PID domain.Contains 1 Rab-GAP TBC domain.SEQUENCE CAUTION: The sequence BAB55057.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-phospho-TBC1D1 (Ser237) View All» Concentration: 0.50 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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