货号：07-2264

品牌：Merck Millipore

规格：

目录价：￥3821.00

市场价格：￥3247.85

会员价格：￥3056.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-OSR1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~58 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human OSR1. View All» Background Information: Odd-skipped-related protein 1 (OSR1) is expressed during the beginning stages of embryogenesis in the intermediate mesoderm and in patterns during limb and branchial arch development. It has been shown that OSR1 plays a critical part in creating kidney precursor cells and regulating differentiation into kidney tubular tissue. OSR1 may play a role in limiting endoderm differentiation from mesendoderm. Expression of OSR1 is controlled by Runx2 and Ikzf1 and is key in development of embryonic, heart and urogenital tissue. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Other homologies: Rat (96% sequence homology). View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected OSR1 on 10 µg of HEK293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95747 View All» Entrez Gene Number: NP_005100 View All» Gene Symbol:
  • OSR1

  • OXSR1
    View All» Alternate Names:
    • oxidative-stress responsive 1

    • serine/threonine-protein kinase OSR1

    • Oxidative stress-responsive 1 protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: By autophosphorylation on threonine. SUBUNIT STRUCTURE: Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT. UniProtKB Q6P9R2TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 protein kinase domain.SEQUENCE CAUTION: The sequence AAP97192.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA83053.2 differs from that shown. Reason: Frameshift at position 63. View All» Product Name: Anti-OSR1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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