货号：MAB2022

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Keratan Sulfate Antibody, clone EFG-11 | MAB2022 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes 2-3 disaccharide units on both skeletal (type II) and corneal (type I) keratan sulfate chains either in isolated or proteoglycan-bound form. The epitope is resistant to proteolytic or alkaline cleavages and partially sensitive to keratanase or other endo-B-galactosidase treatment. View All» Immunogen: Human articular cartilage proteoglycan digested with chondroitinase ABC. View All» Clone: EFG-11 View All» Isotype: IgG2b View All» Species Reactivity:

• Bovine

• Canine

• Human

• Mouse

• Pig

• Sheep
  View All» Application Notes: Western blot at 1:1000 - 1:4000 ELISA at 1:5,000-1:20,000 RIA at 1:30,000-1:500,000 May be used in a competitive inhibition assay to measure keratan sulfate levels. View All» Presentation: Ascites liquid, no preservative. View All» Storage Conditions: Maintain at -20°C in convenient aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P51884 View All» Entrez Gene Number: NM_002345.3 View All» Gene Symbol:
  • LUM

  • SLRR2D

  • LDC

  • lumican
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Radioimmunoassay

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. View All» UniProt Summary: SIZE: 338 amino acids; 38429 Da SUBUNIT: Binds to laminin (By similarity).SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).TISSUE SPECIFICITY: Cornea and other tissues.DEVELOPMENTAL STAGE: Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.SIMILARITY: SwissProt: P51884 ## Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily. & Contains 12 LRR (leucine-rich) repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Keratan Sulfate Antibody, clone EFG-11 | MAB2022 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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