货号：07-2242

品牌：Merck Millipore

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目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-c-Met (Tyr1230/1234/1235) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes c-Met when phosphorylated at Tyr1230, Tyr1234, and Tyr1235. View All» Molecular Weight: ~145 kDa observed. (Kermorgant, S., et al. (2003). The Journal of Biological Chemistry. 278(31):28921–28929.)An uncharacterized band may appear at ~120 kDa. View All» Epitope: Phosphorylated Tyr1230, Tyr1234, Tyr1235 View All» Immunogen: KLH-conjugated linear peptide corresponding to human c-Met phosphorylated at Tyr1230, Tyr1234, and Tyr1235. View All» Modifications:

• Phosphorylation

• Phosphorylation

• Phosphorylation
  View All» Background Information: The c-MET protein (c-MET) is also sometimes referred to as the hepatocyte growth factor (HGF) receptor and is thought to be involved in angiogenesis, cellular motility, growth, invasion and differentiation. c-MET is a heterodimer made up of a 50 kda (alpha) disulfide linked chain and a 145 kda (beta) disulfide linked chain. c-MET has been shown to be greatly amplified in the gastric carcinoma cell line and this amplification has been linked to an advanced tumor stage and a poorer prognosis. c-MET has been shown to decrease the viability and growth of small cell lung cancer cell lines specifically and may be an interesting target for potential therapies for cancer in general. View All» Species Reactivity:
  • Human

  • Mouse

  • Rat

  • Canine

  • Chimpanzee

  • Feline
    View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, canine, chimpanzee, and feline based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected c-Met in NIH/3T3 and HeLa cells. View All» Control: HGF treated and untreated HeLa cell lysates View All» Quality Assurance: Evaluated by Western Blot in HGF treated and untreated HeLa cell lysates.Western Blot Analysis: 1 µg/mL of this antibody detected c-Met on 10 µg of HGF treated and untreated HeLa cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P08581 View All» Entrez Gene Number: NP_000236 View All» Gene Symbol: MET View All» Alternate Names:
    • Hepatocyte growth factor receptor

    • HGF receptor

    • HGF/SF receptor

    • Proto-oncogene c-Met

    • Scatter factor receptor

    • SF receptor

    • Tyrosine-protein kinase Met
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SUBUNIT STRUCTURE: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: The kinase domain is involved in SPSB1 binding.INVOLVEMENT IN DISEASE: Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.Note=Defects in MET may be associated with gastric cancer.Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family.Contains 3 IPT/TIG domains.Contains 1 protein kinase domain.Contains 1 Sema domain. View All» Product Name: Anti-phospho-c-Met (Tyr1230/1234/1235) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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