货号：MAB2013

品牌：Merck Millipore

规格：

目录价：￥4657.00

市场价格：￥3958.45

会员价格：￥3725.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-K-Cadherin Antibody, extracellular domain, clone 2B6 | MAB2013 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with the extracellular domain of K-cadherin. View All» Epitope: extracellular domain View All» Immunogen: Affinity purified extracellular domain of human K-cadherin View All» Clone: 2B6 View All» Isotype: IgG1 View All» Background Information: Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived. View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Western blot: 1:25 - 1:250 Immunohistochemistry: 1:25 - 1:50; Frozen tissue sections with avidin-biotinylated horseradish peroxidase complex (ABC) as the detection method. Optimal working dilutions must be determined by the end user.I/ View All» Presentation: Purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide. View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: P55285 View All» Entrez Gene Number: NM_004932.2 View All» Gene Symbol:
  • CDH6

  • K-cadherin

  • KCAD
    View All» Alternate Names: Cadherin-6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. View All» UniProt Summary: FUNCTION: SwissProt: P55285 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.SIZE: 790 amino acids; 88309 Da SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.SIMILARITY: SwissProt: P55285 ## Contains 5 cadherin domains. View All» Brand Family: Chemicon View All» Product Name: Anti-K-Cadherin Antibody, extracellular domain, clone 2B6 | MAB2013 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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