货号：07-2188

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho LRP-6 (Ser1607) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LRP-6 when phosphorylated at Ser1607 (E motif). View All» Molecular Weight: ~180 kDa observed View All» Epitope: Phosphorylated Ser1607 View All» Immunogen: KLH-conjugated linear peptide corresponding to human LRP-6 phosphorylated at Ser1607. View All» Modifications: Phosphorylation View All» Background Information: LRP-6, LDL receptor-related protein 6, is a single-span transmembrane protein that is a member of the Wnt signaling pathway that regulates embryonic development and stem cell proliferation. The deregulation of the Wnt signaling pathway is involved in human bone diseases and malignancies. Recently LRP-6 has also been found to be involved in the insulin signaling pathway, which is important in metabolic diseases and in cellular processes. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with human based on 100% sequence homology. View All» Control: MEF1 untreated and Wnt3a treated cell lysates View All» Quality Assurance: Evaluated by Western Blot in MEF1 untreated and Wnt3a treated cell lysates.Western Blot Analysis: 1:250 dilution of this antibody detected LRP-6 on 10 µg of MEF1 untreated and Wnt3a treated cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O75581 View All» Entrez Gene Number: NP_002327 View All» Gene Symbol:
  • LRP-6

  • ADCAD2

  • LRP6
    View All» Alternate Names:
    • low density lipoprotein receptor-related protein 6

    • low-density lipoprotein receptor-related protein 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis. SUBUNIT STRUCTURE: Interacts with RSPO1 and RSPO3 By similarity. Interacts with FZD5. Essential component of the Wnt7 receptor complex. Wnt7A interacts with the LRP6/FZD5 complex. This interaction is antagonized by DKK1 and DKK3.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane proteinPotential. TISSUE SPECIFICTY: Widely co-expressed with LRP5 during embryogenesis and in adult tissues.DOMAIN: The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1. INVOLVEMENT IN DISEASE: Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947]. SEQUENCE SIMILARITIES: Belongs to the LDLR family.Contains 4 EGF-like domains.Contains 3 LDL-receptor class A domains.Contains 20 LDL-receptor class B repeats. View All» Product Name: Anti-phospho LRP-6 (Ser1607) View All» Concentration: 0.34 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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