货号：07-2174

品牌：Merck Millipore

规格：100Ug

目录价：￥4442.00

市场价格：￥3775.70

会员价格：￥3553.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Heat Shock Protein 90α View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Heat Shock Protein 90α at the N-terminus. View All» Molecular Weight: ~ 90 kDa observed View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human Heat Shock Protein 90α. View All» Background Information: The Heat Shock Protein 90 family is known as a group of molecular chaperones involved in the regulation of maturation, degradation, and folding transport for a select, yet varied group of proteins primarily comprised of signaling molecules, but also including tyrosine kinases, G-protein subunits, transcription factors, and telomerase. Heat Shock Protein 90 has two isoforms that share a homology of 76%; Heat Shock Protein 90α (HSP90α) and Heat Shock Protein 90β (HSP90β). HSP90α contains a charged sequence linker, a C-terminal domain, and N-terminal domain and a middle domain. It is induced by oxidative stress and has been observed in exosomes where it is secreted into the extracellular environment following translocation via TGFα stimulus. Extracellular HSP90α functions to facilitate the migration of both dermal and epidermal cells through its interaction with cell surface receptors CD91 and LRP1. HSP90α interaction with TERT is a necessary component of TERT holoenzyme complex assembly and stabilization. It has also been shown to interact with a variety of other proteins such as FNIP1, HSF1, TOM34, AHSA1, SMYD3, and DNAJC7. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Canine
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with canine based on 100% sequence homology. View All» Application Notes: Western Blot (Snap i.d.®) Analysis: 1 µg/mL from a previous lot detected Heat Shock Protein 90α on 10 µg of NIH/3T3 cell lysate.Immunohistochemistry Analysis: 1:100 dilution from a previous lot detected Heat Shock Protein 90α in human prostate adenocarcinoma tissue.Immunocytochemistry Analysis: 1:500 dilution from a previous ot detected Heat Shock Protein 90α in A431 cells.Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated Heat Shock Protein 90A from HeLa cell lysate. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.0625 µg/mL of this antibody detected Heat Shock Protein 90α on 10 µg of HeLa cell lysate. View All» Purification Method: Protein A View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07900 View All» Entrez Gene Number: NP_001017963 View All» Gene Symbol:
  • HSP90AA1

  • HSPCAL4

  • HSPN

  • HSP86

  • Hsp89

  • HSP90N

  • HSPC1

  • HSP90A

  • Hsp90

  • HSPCAL1

  • HSPCA

  • LAP2
    View All» Alternate Names:
    • heat shock protein 90kDa alpha (cytosolic), class A member 1

    • Renal carcinoma antigen NY-REN-38

    • heat shock 90kD protein 1, alpha

    • heat shock 90kD protein, alpha-like 4

    • heat shock 90kDa protein 1, alpha

    • heat shock protein HSP 90-alpha

    • Heat shock 86 kDa

    • heat shock 90kD protein 1, alpha-like 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Molecular chaperone. Has ATPase activity (By similarity).SIZE: 732 amino acids; 84660 Da SUBUNIT: Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1.SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.SIMILARITY: Belongs to the heat shock protein 90 family. View All» Product Name: Anti-Heat Shock Protein 90α View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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