货号：MAB1984

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin α5β1 Antibody, clone BMA5 | MAB1984 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with the mouse fibronectin receptor alpha5beta1 complex. View All» Clone: BMA5 View All» Isotype: IgG2bκ View All» Species Reactivity: Mouse View All» Application Notes: Flow cytometry, 1:100 or 10 microliters per 10E6 cells. Inhibition of VLA-5 mediated cell adhesion to fibronectin is generally achieved at 10 microliters per 100 microliters of cell suspension containing 10E6 cells. Immunohistochemistry: Acetone or lightly fixed PFA fixed tissues only; traditional formalin fixation is not recommended. Immunoprecipitation of VLA-5 from lysate of 10E6 cell equivalent requires 5 microliters of BMA5 in no more than 500 microliters cell lysate (As the antibody recognizes the integrin complex, it will not detect alpha5 or beta1 subunits in western blots. Final working dilutions must be determined by end user. Cell lines tested by using BMA5 to express VLA-5 include: mouse bone marrow-derived mast cells, melanoma cell line B16F1, squamous carcinoma SCC-VII, fibroblast cell line NIH-3T3, splenic T lymphocytes, thymocytes and various T cell lines. View All» Applications Not Recommended: Western Blotting View All» Presentation: Liquid, no preservatives. View All» Storage Conditions: Maintain at -20 °C for up to 12 months. View All» UniProt Number: P08648 View All» Entrez Gene Number: NM_002205.2 View All» Gene Symbol:

• ITGA5

• VLA-5

• CD49e

• VLA5A

• FNRA
  View All» Alternate Names: VLA-5; Fibronectin Receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunoprecipitation

  • Affects Function
    View All» Entrez Gene Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. View All» UniProt Summary: FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SIZE: 1049 amino acids; 114536 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin α5β1 Antibody, clone BMA5 | MAB1984 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Rat View All»
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