货号：07-2116

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-RSK3 (Ser360) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RSK3 when phosphorylated at Ser360. View All» Molecular Weight: ~85 kDa observed View All» Epitope: Phosphorylated Ser360 View All» Immunogen: KLH-conjugated linear peptide corresponding to human RSK3 phosphorylated at Ser360. View All» Modifications: Phosphorylation View All» Background Information: RSK3 (Ribosomal S6 kinase 3) is a novel pp90rsk Ser/Thr kinase and the RSK family of kinases can be activated by MAP kinases. RSK3 is thought to activate the Ras/extracellular signal-regulated kinase (ERK1/2) which is involved in cell growth, proliferation, survival and motility. RSK3 remains active longer than other RSK’s and stays attached to the ERK1/2 complex. RSK3 has a turn motif phosphate in the tail that has a phosphoSer/Thr-binding site and is thought to be the main mechanism of activation. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Pig

• Rhesus Macaque

• Bovine

• Horse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, porcine, rhesus macaque, bovine, and equine based on 100% sequence homology. View All» Control: Untreated and EGF treated MCF-7 cell lysates View All» Quality Assurance: Evaluated by Western Blot in untreated and EGF treated MCF-7 cell lysates.Western Blot Analysis: 2 µg/mL of this antibody detected RSK3 on 10 µg of untreated and EGF treated MCF-7 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15349 View All» Entrez Gene Number: NP_001006933 View All» Gene Symbol:
  • HU-2

  • MAPKAPK1C

  • RSK

  • RSK-3

  • RSK3

  • S6K-alpha

  • S6K-alpha2

  • p90-RSK3

  • pp90RSK3
    View All» Alternate Names:
    • 90 kDa ribosomal protein S6 kinase 2

    • MAP kinase-activated protein kinase 1c

    • Ribosomal S6 kinase 3

    • S6K-alpha 2

    • p90-RSK 2

    • ribosomal protein S6 kinase alpha 2

    • ribosomal protein S6 kinase, 90kD, polypeptide 2

    • ribosomal protein S6 kinase, 90kDa, polypeptide 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. View All» UniProt Summary: FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium.ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues (By similarity).SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).SUBCELLULAR LOCATION: Nucleus TISSUE SPECIFICITY: Expressed in many tissues. Highest expression in lung and skeletal muscle. PTM: Autophosphorylated on Ser-377, as part of the activation process (By similarity). SEQUENCE SIMILARITIES: Belongs to the protein kinase super family. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 2 protein kinase domains. View All» Product Name: Anti-phospho-RSK3 (Ser360) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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