货号：07-2115

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-RSK4 (Ser372) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RSK4 phosphorylated at Ser372. View All» Molecular Weight: ~80 kDa observed View All» Epitope: Phosphorylated Ser372 View All» Immunogen: KLH-conjugated linear peptide corresponding to human RSK4 phosphorylated at Ser372. View All» Modifications: Phosphorylation View All» Background Information: RSK1, RSK2, RSK3, and RSK4 (ribosomal protein S6 kinase, 90 kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases. Ribosomal S6-kinase 4 (RSK4) is thought to be mapped in the critical region that is commonly deleted in X-linked deafness type 3, mental retardation, and choroideremia. It may be involved in normal neuronal development. RSK4 is also thought to play a role in non-growth factor signaling and may also be important in tumor suppression. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology. View All» Control: EGF treated and untreated PC-12 cell lysates View All» Quality Assurance: Evaluated by Western Blot in EGF treated and untreated PC-12 cell lysates.Western Blot Analysis: 2 µg/mL of this antibody detected RSK4 on 10 µg of EGF treated and untreated PC-12 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UK32 View All» Entrez Gene Number: NP_055311 View All» Gene Symbol:
  • PP90RSK4

  • RSK-4

  • RSK4

  • pp90RSK4
    View All» Alternate Names:
    • 90 kDa ribosomal protein S6 kinase 6

    • Ribosomal S6 kinase 4

    • S6K-alpha 6

    • p90-RSK 6

    • ribosomal protein S6 kinase polypeptide 6

    • ribosomal protein S6 kinase, 90kD, polypeptide 6

    • ribosomal protein S6 kinase, 90kDa, polypeptide 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. View All» UniProt Summary: FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium (By similarity).ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues (By similarity).SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).PTM: Autophosphorylated on Ser-389, as part of the activation process (By similarity). SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 2 protein kinase domains. View All» Product Name: Anti-phospho-RSK4 (Ser372) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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