货号：07-2065

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SET2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SET2. View All» Molecular Weight: 231 kDa View All» Epitope: C-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding the C-terminal region of human SET2. View All» Background Information: SET2 is a histone methyltransferase that methylates Lys36 of histone H3. H3Lys36 methylation represents a specific tag for epigenetic transcriptional activation. This protein plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SET2 binds DNA at promoters, and may act as a transcription activator. SET2 also binds to the promoters of adenovirus 12 E1A gene during infection, possibly leading to regulation of its expression. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Not tested in other species. View All» Application Notes: ELISA:This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000). View All» Quality Assurance: Immunohistochemistry:1:100 dilution of this antibody detected SET2 in formalin-fixed, paraffin-embedded human lung tissue. Myocytes are immunoreactive. View All» Purification Method: Protein G chromatography View All» Presentation: Purified rabbit polyclonal in buffer containing 0.09% NaN3. View All» Storage Conditions: Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9BYW2 View All» Entrez Gene Number: NP_054878 View All» Gene Symbol:

• SET2

• hSET2

• p231HBP

• EC 2.1.1.43

• FLJ16420

• FLJ22472

• FLJ23184

• FLJ45883

• FLJ46217

• HIF-1

• HIF1

• HSPC069

• HYPB

• KIAA1732

• KMT3A
  View All» Alternate Names:
  • Huntingtin yeast partner B

  • Huntingtin-interacting protein 1

  • Huntingtin-interacting protein B

  • Lysine N-methyltransferase 3A

  • SET domain containing 2

  • SET domain-containing protein 2

  • histone-lysine N-methyltransferase SETD2

  • huntingtin interacting protein 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Ref.5Catalytic activity S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.SUBUNIT STRUCTURE: Specifically interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats doubly phosphorylated on 'Ser-2' and 'Ser-5' of each heptad. Interacts with HTT. Ref.5 Ref.3 Ref.9 Ref.10 Ref.15SUBCELLULAR LOCATION:NucleusProbable. TISSUE SPECIFICITY: Ubiquitously expressed. Ref.3DOMAIN: The low charge region mediates the transcriptional activation activity.PTM: May be automethylated. Ref.5SEQUENCE SIMILARITIES: Belongs to the histone-lysine methyltransferase family. SET2 subfamily.Contains 1 AWS domain.Contains 1 post-SET domain.Contains 1 SET domain.Contains 1 WW domain.SEQUENCE CAUTION: The sequence AAF29041.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAH72440.1 differs from that shown. Reason: Erroneous termination at position 463. Translated as Glu.The sequence CAC28349.1 differs from that shown. Reason: Erroneous termination at position 385. Translated as Arg. View All» Product Name: Anti-SET2 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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