货号：07-2048

品牌：Merck Millipore

规格：

目录价：￥4113.00

市场价格：￥3496.05

会员价格：￥3290.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HSPBAP1 Antibody (07-2048) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects all 3 isoforms of human HSPBAP1 in Western blots. View All» Molecular Weight: ~55 kDa View All» Epitope: C-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding to the C-terminal region of human HSPBAP1. View All» Background Information: Heat Shock Protein BAP1 (heat shock 27-kDa-associated protein 1, or HSPBAP1) inhibits the function of heat shock protein 27, which has a neuroprotective effect during experimentally induced epileptic neuropathology. The HSPBAP1 protein, also known as PASS1, contains a jmjC motif, suggesting it is a member of the jumonji family of transcription factors. There is evidence of domain swapping within the jumonji family genes, and the HSPBAP1 gene has been shown to fuse with a novel gene called DIRC3 in hereditary renal cell cancer. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Human, mouse. Not tested in other species. View All» Application Notes: ELISA: This antibody was reported by an outside laboratory to be suitable for ELISAImmunohistochemistry: This antibody was reported by an outside laboratory to be suitable for immunohisto-chemistry.Immunocytochemistry:A 1:100 dilution of anti-HSPBAP1 polyclonal antibody was used.Western blotting:Western blot analysis of anti-HSPBAP1 in Jurkat cell lysate. All three isoforms of HSPBAP1 are detected. The accession numbers of the isoforms are: Q96EW2; Q96EW2-2; Q96EW2-3. View All» Control: A431, HeLa, or NIH/3T3 cells View All» Quality Assurance: ImmunocytochemistryDetects HSPBAP1 in the nuclei of A431, HeLa, or NIH/3T3 cells in immunofluorescent analysis. View All» Purification Method: Protein G chromatography View All» Presentation: Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q96EW2 View All» Entrez Gene Number: NP_078886.2 View All» Gene Symbol:
  • FLJ22623

  • FLJ39386

  • PASS1
    View All» Alternate Names:
    • 27 KdA heat shock protein-associated protein 1

    • HSPB (heat shock 27kD) associated protein 1

    • HSPB (heat shock 27kDa) associated protein 1

    • Hspb associated protein 1

    • Protein associated with small stress protein 1

    • heat shock 27 kDa associated protein

    • protein associating with small stress protein PASS1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • ELISA

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: May play a role in cellular stress response By similarity.SUBUNIT STRUCTURE: Interacts with CRYAB and HSPB1. Ref.4SUBCELLULAR LOCATION: CytoplasmBy similarity. TISSUE SPECIFICITY: Widely expressed. Ref.1DISEASE: A chromosomal aberration involving HSPBAP1 is found in familial renal cell carcinoma 1 (RCC1) [MIM:144700]. Translocation t(2;3)(q35;q21) with the putative pseudogene DIRC3. Produces an hybrid mRNA encoding a truncated HSPBAP1 lacking the first 36 amino acids.SIMILARITY: Contains 1 JmjC domain. View All» Product Name: Anti-HSPBAP1 Antibody (07-2048) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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