货号：MAB1924

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Laminin α5 Antibody, clone 4C7 | MAB1924 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with the globular domain of the alpha5 chain of intact laminin and blocks the neurite stimulating activity of laminin. This antibody was originally thought to recognize laminin alpha 1 or A, but further characterization has confirmed its specificity for the laminin alpha 5 chain [see Tiger, C.F. (1997) J. Biol. Chem. 272: 28590]. View All» Immunogen: Purified human laminin View All» Clone: 4C7 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: ELISA (50% maximal binding to human laminin): >1:11,000. Immunofluorescence - tissue staining pattern is most consistent with that observed for laminin alpha5 in the mouse(Miner et al., 1997) Affinity chromatography Immunoprecipitation Does not work for Western blotting Optimal working dilutions must be determined by end user. View All» Control: Developing striated muscle tissue View All» Purification Method: Unpurified View All» Presentation: UnPurified mouse ascites containing no preservatives. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: O15230 View All» Entrez Gene Number: NM_005560.3 View All» Gene Symbol:

• LAMA5

• KIAA1907

• KIAA0533
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunohistochemistry

  • Immunoprecipitation
    View All» Entrez Gene Summary: Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: O15230 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.SIZE: 3695 amino acids; 399755 Da SUBUNIT: Laminin-15 complex is an heterotrimer composed of three chains (alpha-5/beta-2/gamma-3) which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.TISSUE SPECIFICITY: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.DOMAIN: SwissProt: O15230 Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.SIMILARITY: Contains 22 laminin EGF-like domains. & Contains 5 laminin G-like domains. & Contains 1 laminin IV type A domain. & Contains 1 laminin N-terminal domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Laminin α5 Antibody, clone 4C7 | MAB1924 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Ascites View All» Host: Mouse View All»
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